Multiple Sclerosis

Question 1

What population is multiple sclerosis most common in?

Answer 1

• Young (20-40) females at latitudes closer to the poles

Question 2

What are the typical signs/symptoms on presentation in a person with multiple sclerosis?

Answer 2

• Unilateral visual disturbance
  
  • Colour discrimination
  • Cloudy vision
  • Pain on movement of eye
• Sensory disturbance
  
  • Banding or hemi-patterned
• Motor disturbance
• UMN signs
• Cerebellar signs
• Fatigue
• Urinary frequency
• Bowel changes

Question 3

What are the principles of management of multiple sclerosis?

Answer 3

• Acute relapse management
  
  • High dose methylpred/pred
• Disease progression modification
  
  • Immunomodulators (interferons, MAbs, azathioprine etc.)