CVD - cardiometabolic syndrome

Question 1

IDF definition of the metabolic syndrome

Answer 1

Abdominal obesity + 2 or more of:
•Elevated TG (> 1.7 mmol/L) and/or
•low HDL-C (130/85 mmHg) or treatment
•Hyperglycaemia (FPG>5.6mmol/l or IGT or diagnosed type 2 diabetes).

• Europoids (>94 cm M; >80 cm F);
• South Asia & Chinese (>90 cm M; >80 cm F);

Question 2

What does abdominal obesity increase the risk of?

Answer 2

AMI

Question 3

How is metabolic syndrome helpful clinically? (what does it help us predict)?

Answer 3

• increased CVD mortality

- increased risk of CHD & diabetes

Question 4

(3) metabolic syndrome treatment strategies

Answer 4

• address glucose intolerance + prevent diabetes
• address dyslipidaemia (reduce CV risk)
• treat hypertension (reduce CV risk)

Question 5

What (4) drugs can be used to reduce CHD in high risk patients?

Answer 5

• Statins (30-40%)
• ACE inhibition (20-25%)
• Aspirin (10-15%)
• Fibrates (15-25%)

Question 6

What are the current lipid targets for high risk pts from the National Heart Foundation Australia?

• LDL cholesterol
• HDL cholesterol
• Triglycerides
• Non-HDL cholesterol

Answer 6

• LDL-cholesterol 1.0 mmol/L

- Triglycerides