Epithelial Characteristics

Question 1

What is laminin & what does it contain binding sites for?

Answer 1

• Major component of basal lamina; contains 3 chains (alpha, beta, gamma)
• Binding Site: integrins, type IV collagen, entactin, proteoglycans (i.e. heparin sulfate)

Question 2

What is fibronectin made up of? Binding sites?

Answer 2

• 2 polypeptide chains crossed-linked by disulfide bonds
• Binding sites for heparin (proteoglycan), integrins, collagen, fibrin

Question 3

What are the two forms of fibronectin?

Answer 3

1. Cellular - produced by fibroblasts; part of ECM
2. Plasma - secreted into bloodstream by hepatocytes

Question 4

What are the basal lamina components? (5)

Answer 4

1. Laminin
2. Fibronectin
3. Type IV collagen
4. Proteoglycans
5. Nidogen/entactin

Question 5

The basal lamina is associated with which type of collagen:

Type I

Type II

Type IV

Type VII

Answer 5

Type IV

Question 6

Which of the following types of cell adhesion molecules is associated with Zonula occludens and desmosomes?

Cadherins

Integrity

Selections

Ig Superfamily

Answer 6

Cadherins

Question 7

Which of the following serves a major interface between the cadherins that hold adjacent cells together and their actin cytoskeleton?

Proteoglycans

Catenins

Laminins

Keratins

Answer 7

Catenins

Question 8

The extracellular domains of which of the following bind to molecules in the ECM such as fibronectin and laminin?

Cadherins

Integrins

Selectins

Ig Superfamily

Answer 8

Integrins

Question 9

Which of the following are molecule complexes that anchor cells together and reinforce the physical integrity of tissus and the cells that make up the tissues?

Zonula adherens

Zonula occludens

Hemidesmosomes

Connexons

Answer 9

Zonula adherens

Question 10

Which of the following are molecule complexes that primarily serve to prevent paracellular transport?

Zonula adherins

Zonula occludens

Hemidesmosomes

Connexons

Answer 10

Zonula occludens