HEME Flashcards

1
Q

Signs and Sxs:

  • Weakness, faintness, vertigo
  • HA
  • Tachycardia, orthostatic HoTN
  • Cold sensitivity
  • Jaundice
  • Petechiae, pallor, ecchymosis
A

Anemia

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2
Q

Signs and Sxs:

  • Tachycardia, orthostatic HoTN
  • Cold sensitivity
  • Jaundice
  • Petechiae, pallor, ecchymosis
  • Paresthesia, abnormal reflexes, confusion
  • Decreased vibration sense
A

vit B12 deficiency (b/c of neuro sxs)

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3
Q

Signs and Sxs:

  • Mucocutaneous or perioperative bleeding
  • Hx of bleeding after tooth extraction or surgery
A

vonWillebrand dz

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4
Q

Signs and Sxs:

  • Previous thrombosis
  • FHx thrombosis
  • Thrombosis in unusual locations like sagittal sinus, mesentery, portal systems
A

Factor V Leiden

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5
Q

Signs and Sxs:

  • platelets decrease by 50%
  • skin necrosis, ischemic changes, bleeding
A

HIT heparin induced thrombocytopenia

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6
Q

Lab Workup for Anemia

A
  • CBC with indices
  • Retic count
  • Peripheral smear
  • Stool sample for occult blood
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7
Q

Normal Hgb Values

A
  • M: 13-17

- F: 12-15

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8
Q

Normal HCT Values

A
  • M: 39-49

- F: 35-45

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9
Q

Normal WBC Count

A

4000-11000

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10
Q

Normal Platelet Count

A

150,000-400,000

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11
Q

Normal Retic Count

A

2.5

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12
Q

3 Examples of Microcytic (MVC under 80) Anemias

A
  • iron deficiency
  • anemia of chronic dz (late)
  • sickle cell and thalassemia
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13
Q

3 Examples of Normocytic (MVC 80-100) Anemias

A
  • anemia of chronic dz (early)
  • renal failure
  • autoimmune hemolytic
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14
Q

2 Examples of Macrocytic (MVC over 80) Anemias

A
  • vit B12 deficiency

- folate deficiency

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15
Q

Causes of Iron Deficiency

A
  • women: menstruation or pregnancy

- men: GI bleed

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16
Q

Causes of Anemia of Chronic Dz

A
  • malignancy
  • renal failure
  • arthritis
17
Q

Causes of Vit B12 Deficiency

A
  • malabsorption (MC)
  • pernicious anemia
  • Crohn’s
  • surgical resection
18
Q

Causes of Folate Deficiency

A
  • malnutrition

- alcoholism

19
Q

How is iron deficiency anemia diagnosed?

expected lab results

A
  • microcytic
  • low serum iron
  • increased TIBC
  • low ferritin
  • low transferrin
  • no reticulocytosis
20
Q

How is anemia of chronic dz diagnosed?

expected lab results

A
  • increased ferritin
  • normal or low TIBC
  • low transferrin
  • low retic count
21
Q

How is vit B12 deficiency diagnosed?

expected lab results

A
  • comes on slowly
  • macrocytic
  • hypersegmented PMNs
  • smooth red tongue (glossitis)
  • neurologic abnormalities
  • low serum B12
  • Schilling test
22
Q

How is folate deficiency diagnosed?

expected lab results

A
  • macrocytic
  • hypersegmented PMNs
  • smooth red tongue (glossitis)
  • NO neuro sxs
  • low serum folate
  • normal serum B12
23
Q

How is hemolytic anemia diagnosed?

expected lab results

A
  • high retic count
  • warm or cold antibody
  • normochromic, normocytic
  • spherocytes and schistocytes on smear (helmet cells)
  • direct Coomb’s test (positive)
24
Q

Lab Findings for vonWillebrand’s Dz

A
  • platelet count normal
  • PT/INR normal
  • PRR and bleeding time usually prolonged
25
Q

How is Factor V Leiden diagnosed?

A

DNA based test for factor V mutation

26
Q

Lab Findings for Heparin Induced Thrombocytopenia

A
  • platelets decreased 50%

- variation of INR, PTT, fibrinogen