2008 mcq

Question 1

regarding tolerance

Answer 1

most proteins are naturally highly immunogenic
cross linking of surface Ig may cause apoptosis of B-lymphocytes in the bone marrow
central tolerance occurs in the bone marrow and thymus

Question 2

define allograft

Answer 2

a graft from a non identical individual

Question 3

foreign antigen presented by B lymphocytes is taken up usually by?

Answer 3

by the B cell receptor not phagocytosis

Question 4

human graft rejection

Answer 4

not due to beta microglobulin subtypes

Question 5

IL10 ?

Answer 5

antiinflammatory cytokine

promotes Th2 response

Question 6

some factors involved in acute inflammation

Answer 6

COX2, iNOS, platelet activating factor

Question 7

B lymphocytes

Answer 7

do no individually express both kappa and lamba light chains

Question 8

delayed type hypersensitivity type 4 response

Answer 8

mediated by T cells

is significantly associated with mycobacterial infections

Question 9

antibody diversity is generated by

Answer 9

different heavy and light chain combinations
somatic hypermutation
junctional diversity

Question 10

immune response to novel virus

Answer 10

IFNalpha is important reactant
TNFalpha is relevant
IL12 is relevant

Question 11

some viruses that synthesise progeny genomes in the nucleus

Answer 11

herpes
lentivirus
papillomaviruses

Question 12

influenza virus

Answer 12

typically induces upper respiratory tract infections

Question 13

some DNA viruses

Answer 13

HBV, adenoviruses, poxviruses, reoviruses

Question 14

some pathogenic effects of virus infection can be caused by interferon

Answer 14

-

Question 15

trypanosoma brucei gambeniense

Answer 15

causes sleeping sickness