Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Pharm II > Exam 3 immune modulators/antifinflammatory agents for AI > Flashcards

Exam 3 immune modulators/antifinflammatory agents for AI Flashcards

1
Q

MOA of what drug is: reduce inflammation, pain and fever

A

Aspirin and NSAIDS (cornerstones of tx)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

MOA of what drug is: interferes with prostaglandin synthesis

A

sulfasalazine (Azulfidine) (Used for tx of RA when NSAIDS are inadequate)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

MOA of what drug is: Inhibits pyrimidine synthesis, resulting in anti-proliferatice and anti-inflammatory effects

A

lefunomide (Arava)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

MOA of what 3 drugs is an TNF alpha blocker - binds to TNF molecules and blocks interaction with cell surface receptors

A

entanercept (Enbrel)
inflizimab (Remicade)
adalimumab (Humira)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

MOA of what drug is an interleukin 1-receptor antagonist (blocker)

A

anakinra (Kineret)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

5 categories that make up DMARDS (disease modifying anti-rheumatic drugs)

A
  1. Immune modulators
  2. Anticytokine therapies
  3. Antimalarials
  4. Penicillamine
  5. Gold (unknown mechanism, many possibilities)
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

When are DMARDS used?

A

On pts who do not respond to cox2 inhibitors - slows course of disease (RA/OA) may induce remission and prevent further destruction of joints/tissue

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Which drug depresses circulating IgM rheumatodi factor, and depresses Tcell activity?

A

Penicillamine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

2 classes of immunosuppressants used to treat AI diseases

A
  1. cyclosporine

2. steroids

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Which drug inhibits the production and release of interleukin II and inhibits interleukin II induced activation of resting T lymphocytes?

A

cyclosporine (Sandimmune, Gengraf, Neoral, Restasis)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Which drug Increase in concentration in neutrophils and decrease in lymphocytes, monocytes, eosinophils, and basophils. It also inhibits phospholipase A, IL-2 migration, and decrease production of both prostaglandins and leukotrienes from arachidonic acid

A

Steroids

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

4 Aspirin side effects

A

1, GI ulceration and bleeding

  1. Kidney retention of sodium and water - may cause hyperkalemia and edema
  2. Tinnitus (sign of toxicity)
  3. respiratory acidosis (toxicity)
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

4 side effects of sulfasalazine (Azulfidine)

A
  1. headache
  2. photosensitivity
  3. GI distress
  4. anorexia
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

5 side effects of celebrex (cox2 inhibitor)

A
  1. stroke
  2. decreases effectiveness of BP meds
  3. MI
  4. Bleeding - asses when using warfarin
  5. cross sensitivity with NSAIDS allergy
  6. contraindicated with sulfonamide allergy
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

What drug can cause prolonged bleeding and oral aphthous ulcerations/aphthous stomatitis?

A

aspirin and NSAIDS

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

What drug can cause mucosal ulcerations?

A

methotrexate (Rheumatrex, Trexall)

17
Q

What 2 drugs can cause blue black intraoral pigmentation?

A
  1. chloroquine (Aralen)

2. hydroxychloroquine (Plaquenil)

18
Q

4 oral side effects of penicillamine

A
  1. infection
  2. delayed healing
  3. prolonged bleeding
  4. oral ulceration
19
Q

What drug causes dermatitis with mucosal ulcerations, infection, delayed healing, prolonged bleeding, glossitis, aphthous stomatitis, blue black intraoral pigmentation

A

Gold compounds

20
Q

What immunosuppressive drug can cause gingival hyperplasia

A

cyclosporine

21
Q

Important dental practice considerations for patients taking immune modulators

  1. Vital signs taken - ____ ___ may be due to chronic pain or medication-induced _____ _____ from antihypertensives.
  2. Obtain recent ___ ___ - checks if predisposed to other infections, multiple ____ = affects liver and kidneys (organ dysfunction)
  3. Most do not require _____ ___- consult physician if cardiac/kidney involvement, will need a pre-med if pt has AI plus a ____ ____ ____.
  4. Stress caused by anxiety, anticipation of pain, infections or surgical procedures significantly raises ____ and ____ of ____.
A 
elevated BP
orthostatic hypotension
blood studies
medications
antibiotic premed
prosthetic joint replacement
production
secretion
cortisol
22
Q

4 stress reduction procedures

A
  1. Increased communication
  2. anti-anxiety meds and nitrous oxide
  3. behavioral interventions
  4. good pain control
23
Q

More important dental practice considerations for patients taking immune modulators.

  1. Have emergency ___/____
  2. Create ____ envirnoment
  3. Xerostomia - susceptibility to _____
  4. oral ____
  5. Difficulty eating, speaking, _____
  6. ____ challenges
  7. Depression: ___ of ___ ___
A 
plan/prevention
safe
infections
lesions
swallowing
dexterity
lack of self care
24
Q

4 dental interventions to help a pt with AI diseases

A
  1. hydration/lubricants
  2. fluorides/remineralization/xylitol
  3. antimicrobial rinses
  4. power assisted devices

Pharm II (18 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions