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microbology > General principals > Flashcards

General principals Flashcards

1
Q

Structural toxins

A
  1. Endotoxin
  2. Peptidoglycan
  3. Teichoic Acids
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2
Q

Anthrax toxin (LF) mode of action

A

Lethal factor

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3
Q

Endotoxin is

A
  1. Structural toxin
  2. LPS in G - cells outer membrane
  3. Toxic protion is Lipid A
  4. LPS activates macrophages leading to release of TNF-α, IL-1, and IL-6
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4
Q

cAMP inducres

A
  1. Heat labile toxin (LT)
  2. Cholera toxin
  3. Anthrax toxin
  4. Pertussis toxin
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5
Q

Diptheria toxin mode of action

A

ADP ribosyl transferase causing inactivation of eEF-2 inhibiting Protein synthesis

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6
Q

Exotoxin A mode of action

A

ADP ribosyl transferase inactivating eEF-2 inhibiting protein synthesis

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7
Q

Verotoxin mode of aciton

A

Shiga-like

Interferes with 60S ribosomal subunit

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8
Q

Primary mechanism of aherence in most G - cells

A

Pili/fimbriae

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9
Q

Anthrax toxin (EF) mode of action

A

Edema factor: adenylate cyclase

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10
Q

Cytolysins

A

Lyse cells from outside by damaging membrane

  1. C. perfringens alpha toxin: Lecithinase
  2. S. aureus α toxin: forms pores
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11
Q

Exotoxin A organism

A

Pseudomonas

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12
Q

Anthrax toxin (PA) mode of action

A

Protective antigen

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13
Q

Toxins that inhibit protein synthesis

A
  1. Diphtheria toxin
  2. Exotoxin A
  3. Shiga Toxin
  4. Verotoxin
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14
Q

Primary mechanism of aherence in G + cells

A

Teichoic acid

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15
Q

Heat labile toxin organism

A

ETEC

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16
Q

Shiga toxin mode of action

A

Interferes with 60S ribosomal subunit inhibiting Protein synthesis

Enterotoxic, cytotoxic, and neurotoxic

17
Q

Verotoxin organism

A

EHEC

18
Q

Pertussis toxin mode of action

A

ADP ribosylates Gi negative regulator of adynlate cyclase causing increased cAMP

19
Q

Cholera toxin mode of action

A

Stimulates an Adenylate Cyclase by ADP ribosylation of GTP binding protein

20
Q

Some Killers Have Pretty Nice Capsules

A

Bacteria with Capsule

Strep penumoniae

Klebsiella

Haemophilus influenzae

Pseudomonas

Neisseria meningitidis

Cryptococcus neoformans

21
Q

Heat labile toxin (LT) mode of action

A

LT stimulates an Adenylate Cyclase by ADP ribosylation of GTP binding protein

microbology (6 decks)

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