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From Flashcardlet > Radbio unit 6 > Flashcards

Radbio unit 6 Flashcards

0
Q

Dose response for leukemia

A

Linear nonthreshold

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1
Q

Examples of late effects of radn

A

Carcinogenesis
Cataractogenesis
Life span shortened
Genetic damage

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2
Q

What is leukemia and what is latent period

A

Proliferation of WBC

5-7 yrs but still risk up to 20 yrs

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3
Q

Leukemia is due to what type of exposure

A

Gamma

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4
Q

Bone cancer is what type dose response

A

Linear quadratic

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5
Q

Lung cancer is what type of dose response

A

Linear nonthreshold

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6
Q

Early effects

A

NV, desquamation, erythema

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7
Q

Late effects

A

Cataracts, leukemia, cancer, life span shortening, genetic damage

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8
Q

GSD

A

Genetically significant dose - estimated dose received by population….20 milirad

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9
Q

10-25 rule

A

10 rad - never indicate termination
10-25 rad - gray area depends on when in gestation fetus was exposed
More than 25 rad - terminate

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10
Q

Dose of radn will produce twice frequency of genetic mutations would have been observed wo radn

A

Doubling dose

50-250 rad

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11
Q

Lab animals
Early rads
Fruit fly
Mega mouse

A

Life span shortening
Life span shortening
No new mutation but increase existing mutations
No new mutations

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12
Q

Does skin cancer have nonthreshold or threshold

A

Threshold and linear

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13
Q

Thoratrast

A

Liver..spleen

Leukemia

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14
Q

Uranium minors develop what type ca

A

Lung

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15
Q

Marshall Islanders children

A

Thyroid

16
Q

Watch dial painters

A

Bone

17
Q

Ankylosis spondylosis and gamma exposure

A

Leukemia

18
Q

Females with TB

A

Breast Ca

19
Q

Cataracts has what type dose response

A

Threshold nonlinear

20
Q

Genetic damage has what type dose response

A

Linear nonthreshold

21
Q

Latent period for cataracts and is it high or low LET

A

15 yrs
High dose and Let to lens of eye
Threshold is fractionated at 1000 rad

22
Q

Four recessive inheritable disease

A

CF
Hemophilia
Albanism
Tay-sachs

23
Q

Three dominant inheritable disease

A

Huntington chorea
Achrondoplasia
Polydactyly

24
Q

3 stages of fetal development

A

Preimplantation - conception to 10 days

Organogenesis - 2nd to 8th week

Fetal growth - organogenesis to birth

25
Q

Fetal stage most susceptible to radn induced abnormalities

A

Organogenesis

26
Q

Fetal stage considered prenatal or embryonic death

A

Preimplantation

27
Q

Semester most radiosensitive

A

First

28
Q

Additional cytogenetic damage

A

Allergies
Decreased intelligence
Metabolism alterations

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