Absorption

Question 1

T_max

Answer 1

Time that it takes to reach C_max

Question 2

Two main routes of administration

Answer 2

Enteral and Parenteral

Question 3

Factors related to the animal that affect absorption

Answer 3

Blood flow

Absorbing surface area

Connective tissue

Species

Individual variation

Fasted vs Fed

Question 4

Transdermal Administration

Answer 4

Applied topically to have systemic effect

Question 5

Often the rate limiting step controlling absorption

Answer 5

Dissolution

Question 6

Absorption

Answer 6

Movement of the drug from the site of administration into the blood

Question 7

Rate of absorption is determined by

Answer 7

Rate of absorption is determined by gastric emptying time

Question 8

In animals that are unable to take oral medications, sometimes they are given

Answer 8

In animals that are unable to take oral medications, sometimes they are given rectally

Question 9

Excipient

Answer 9

What a drug is compounded with

Question 10

Sublingual absportion bypasses the

Answer 10

Sublingual absportion bypasses the portal vein

Question 11

Factors related to the drug that affect absorption

Answer 11

Molecular Size

Disintegration and Dissolution

Lipid Solubility

Degree of Ionization

Concentration at the absorptive site

Route of administration

Question 12

With respiratory administration the (upper/lower) respiratory tract is best for systemic absorption.

Answer 12

With respiratory administration the (upper/lower) respiratory tract is best for systemic absorption.

Question 13

Parenteral Drug Administration Routes

Answer 13

IV

IM

SQ

IP

Question 14

Disintegration

Answer 14

Physical dispersion of a soild dosage form

Question 15

Drugs that absorb well when given buccal/sublingual

Answer 15

Dormoseden

Buprenorphine

Question 16

Dissolution

Answer 16

Drug molecules enter solution

Question 17

Rate limiting step of transdermal administration

Answer 17

Stratum corneum

Question 18

First Pass Metabolism

Answer 18

Drugs absorbed distal to the oral cavity and proximal to the rectum enter the portal vein and then into the liver where biotransformation may occur

Question 19

Topical drugs are generally intended to have (high/low) absorption into systemic system

Answer 19

Topical drugs are generally intended to have (high/low) absorption into systemic system

Question 20

C_max

Answer 20

Maximum plasma concentration of a drug

Question 21

Topical Administration

Answer 21

Refers to topicall on the skin to achieve local effects

Question 22

Does IV administration undergo absorption?

Answer 22

No, its administered directly into the vein

Question 23

Rectal administration relationship to first pass metabolism

Answer 23

First pass metabolism may be reduced

Question 24

Primary site for drug absorption

Answer 24

Small intestine

Question 25

AUC Graph

Answer 25

Plots plasma concentration of a drug at different time intervals