Role of ADH and Disorders (lecture) Flashcards
What is the source of endogenous ADH?
Posterior pituitary
_________ has an inhibitory action on ADH neurons. _________ has a stimulatory action on ADH neurons.
Norepi
Acetylcholine
What is the site of action of ADH?
Distal tubule and collecting duct
What is the MoA of ADH?
Increase in aquaporins
What disease results from too little ADH influence?
Diabetes Insipidus
What are the two types of diabetes insipidus?
Neurohypophyseal and nephrogenic
What is the treatment of complete neurohypophyseal DI?
DDAVP (ADH analog)
What class of drugs are used in treatment of nephrogenic DI?
Tiazide diuretics
What is the physiologic danger of SIADH?
Dilutional hyponatremia
What three things make up Schwartz-Bartter syndrome (SIADH)?
Increase glomerular filtration
Decreased renin due to increased renal blood flow –> increased Na+ excretion
Increased natriuretic causing increased Na+ excretion
What two hormones are involved in breast feeding and their specific roles?
Oxytocin acts to cause smooth muscle contraction - milk ejection
Prolactin acts to stimulate milk production
What disease, related to pregnancy, causes ischemic necrosis of the anterior pituitary?
Sheehan
How does Sheehan typical present?
No action port partum
What is the most common presentation from a pituitary adenoma?
Visual disturbances
What disease results from increased growth hormone in an adult?
Acromegaly
