Chapter 7: Capsules Flashcards
They are made of gelatin to which glycerin or a polyhydric alcohol.
soft gelatin capsules
An example of polyhydric alcohol
sorbitol
They contain more moisture than hard capsules.
soft gelatin capsules
Moisture content of soft-gelatin capsules
6-10%
They may contain preservatives.
soft gelatin capsules
Examples of preservatives
methylparaben,
propylparaben
This is used to retard microbial growth.
preservatives
They may be oblong, oval or round.
soft gelatin capsules
They are used to encapsulate and hermetically seal liquids, suspensions, pasty materials, dry powders, and even preformed tablets.
soft gelatin capsules
They are pharmaceutically elegant and easily swallowed.
soft gelatin capsules
Three methods of preparation of soft gelatin capsules
plate process,
rotary die process,
reciprocating die process
In this process of preparation of soft gelatin capsules, a warm sheet of plain or colored gelatin isplaced on the bottom plate of the mold andthe medication-containing liquid is evenlypoured on it.
plate process
In this process of preparation of soft gelatin capsules, liquid a gelatin flowing from an overhead tank is formed into two continuous ribbons by the rotary die machine and brought together between twin rotating dies.
soft gelatin capsules
He developed rotary die process.
Robert Scherer
This process of preparation of soft gelatin capsules is similar to the rotary die process in that ribbons of gelatin are formed and used to encapsulate the fill but it differs in the encapsulating process.
reciprocating die process
