Connective Tissue Disease Flashcards
TRUE or False
People with high oestrogen levels are more likely to suffer from Systemic Lupus Erythematosus?
TRUE
What virus has an association with Systemic Lupus Erythematosus?
Epstein-Barr Virus
What may UV light stimulate in SLE?
skin cells to secrete cytokines stimulating B cells
What do necrotic cells release in SLE?
nuclear material which act as potential autoantigens.
What do the autoantigens stimulate?
B and T cells
autoantibodies
What symptoms accompany SLE?
Fever Malaise Poor appetite Weight loss Fatigue
What mucocutaneous features appear in SLE?
photosensitivity
malar rash
discoid lupus erythmatosus
subacute cutaneous lupus
What musculoskeletal features are involved in SLE?
polyarthtitis/polyarthralgia deforming arthropathy Jaccoud's arthritis erosive arthritis myopathy, myalgia and myositis
What pulmonary features are associated with SLE?
Pleurisy Infections Diffuse lung infiltration and fibrosis Pulmonary hypertension Pulmonary infarct
What cardiac problems are associated with SLE?
Pericarditis
Cardiomyopathy
Pulmonary hypertension
Libman-Sachs endocarditis
How would glomeruloephritis present itself?
Proteinuria Urine sediments Urine RBC and casts Hypertension Acute renal failure Chronic renal failure
What neurological features are associated with SLE?
Depression/psychosis Migranous headache Cerebral ischaemia Cranial or peripheral neuropathy Cerebellar ataxia
What haematological features of SLE are there?
Lymphodenopathy
Leucopenia
Anaemia
Thromboctopenia
What investigations should be done for SLE?
FBC Renal function tests including urine examination Anti-nuclear antibody Anti-double stranded DNA antibodies ENA Complement levels
What is a positive anti-nuclear antibody test?
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