NSAID and gout

Question 1

describe the classic inflammatory symptoms

Answer 1

REDNESS (rubor)

SWELLING (Tumor)

HEAT (calor)

PAIN (dolar)

Question 2

What are the functional characteristics of NSAIDS

Answer 2

• Analgesia
• antipyretic
• anti-inflammatory
• Primary targets = prostaglandin production via cycloxygenases COX-1 and COX-2
• PGE2 and PGI2 are main players (increased edema and vascular permeability)

ACETAMINOPHEN IS NOT AN NSAID

Question 3

Cox-1

Answer 3

• Constitutively expressed, widely distributed, has “housekeeping functions
  
  • synthesis of prostglandins in stomach mucosa that protect stomach lining fromg astric acid

Question 4

Cox-2

Answer 4

• Inducible, production of inflammatory molecules
• COX-2 expressed in vascular endothelium: prostacyclin (PGI2)
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