Extracellular Matrix

Question 1

ECM is found where

Answer 1

Material outside the cell

Question 2

3 main components in ECM

Answer 2

Proteoglycan aggregates, collagen fibers and elastin

Question 3

ECM is a barrier for what

Answer 3

tumor cells seeking to invade new tissues

Question 4

some tumor cells secrete what

Answer 4

heparinase that degrades ECM

Question 5

Proteoglycans are what

Answer 5

different glycosaminoglycans that are linked to the core protein

Question 6

Linkage from what to what in proteoglycans

Answer 6

Linkage from anomeric carbon of xylose to serine hydroxyl group.

Question 7

Proteoglycans are found where

Answer 7

cell surface or in ECM

Question 8

Hyaluronic acid acts as what

Answer 8

shock absorber and lubricant

Question 9

example of modern medicine and carbs

Answer 9

vaccine development and drug development

Question 10

Intervention in glycan communication events are essential for

Answer 10

disease

Question 11

Carbohytrates/glycans receptors and the proteins receptors that specifically bind them can be targeted for what

Answer 11

therapeutic invertion if this interaction is essential for disease progression

Question 12

Therapeutic intervention may be achieved by what 2 ways

Answer 12

1. Creating an antibody specific for a glycan/carbohydrate OR the corresponding protein binding site, so that “communication events” can not occur For Example: Vaccine to block cancer cell communication
2. Creating a drug-mimic that binds to a glycan/carbohydrate binding site with higher affinity than the naturally occurring sugar receptor.
   For Example – Drugs to block infectious disease communication with host cells