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Medicine 2 > Hema 2 > Flashcards

Hema 2 Flashcards

1
Q

Conglomeration of blast cells in skins

A

Chloroma

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2
Q

Leukostasis seen only whenwbc is

A

> > 50 to the 9

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3
Q

Anemia in acute leuk?

A

Normocytic

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4
Q

Acute leuk defined as presence of?

A

> 20% blasts in bone marrow

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5
Q

In light microscopy, +auer rods?

A

Aml

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6
Q

T/f: adult has poor prognosis

A

True

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7
Q

Total eradication of blasrs

A

Complete remission

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8
Q

Phases of acute lymph leuk

A

Induction
Intensification
Cns prophy
Maintenance

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9
Q

Phases of amlp

A

Induction

Consolidation

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10
Q

Peak onset of cmpds

A

50-70

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11
Q

Mpds (6)

A 
Pt
Prv
Mf
Cml
Cel
Unclassifiable
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12
Q

Histamine levels increase in prv

A

Peptic ulceratin

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13
Q

Rcm in PRVin females

A

32

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14
Q

Prv course leads to

A

MF

Acute leukemia

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15
Q

Most common complaint of cll

A

Fatigue

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16
Q

Most common LN affected in CLL

A

Cervical

Supra clav

17
Q

Blood smears in CLL?

A

Basket or smudge

18
Q

Immunotyping inCLL results?

A

99%clonal expansion of B

19
Q

Typical B cell is unique how?

A

Cd19 and cd5+

20
Q

Bone marrow aspirate of CLL?

A

30% lymphocytes

21
Q

Not routinely done in CLL

A

Bm biopsy

Cutogenetic analysis

22
Q

Confirm dx of CLL

A

Immunotyping

23
Q

What stage? Lymphocytosis + anemia of CLL

A

3

24
Q

Binet class c for CLL?

A

Any # involved areas

Hgb

25
Q

Markers for poor prognosis of CLL

A

Abnormal karyotype

Doubling time

26
Q

Pharma tx of CLL

A 
Alkylating agent (chlorambucil, cyclophos)
Nucleoside analogs (cladribine...)
27
Q

Give cytokines that stimulate MM prolif

A

IL6,1

28
Q

Mgt for hypercalcemia inMM (dt bone destruction)

A

Bisphosphonates

Rehydrate

29
Q

Most common presenting sx of MM

A

Bone pain/fracture

30
Q

Faconi syndrome?

A

In MM, type 2 proximal tube acidosis

31
Q

T/f? In MM, there is protenuria with hyertension

A

F no hPn

32
Q

Give 3 dx tests for MM

A

BM aspirate plasma cells >20%
Lytic bone lesions
Serum/urine M comp

33
Q

Symptoms of acute leukemia dt

A 
Marrow failure
Tissue infil
Leukostasis
Constitutional symp
Dic

Medicine 2 (9 decks)

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