3.0 Pituitary

Question 1

Transient fcnl changes in the lactotrope population are induced by?

Answer 1

Estrogen

Question 2

PRL highest secretory peaks occur at?

Answer 2

rem sleep

Question 3

Curculating half life of PRL is

Answer 3

50min

Question 4

Play a central role in mgt of hyperPRL disorders

Answer 4

Dooamine agonists

Question 5

Prl acts to induce and maintain?

Answer 5

Lactation

Question 6

What do PRL do in the ovary

Answer 6

Blocks folliculogenesis and inhibis granulosa cell aromatase activitt

Question 7

Most abundant anterior pit hormone

Answer 7

gh

Question 8

cells that coexpress PRL with GH

Answer 8

mammosomatotrope

Question 9

gastric dervied peptide that induceGHRH and stimulate GH release

Answer 9

ghrelin

Question 10

inhibits GH secretion and sets basal GH tone

Answer 10

somatostatin

Question 11

peripheral target hormone for GH

Answer 11

IGF 1

Question 12

GH secretion highest when?

Answer 12

at night, sleep onset

Question 13

elevated GH levels occur at?

Answer 13

an hour of deep sleep 
after exercise
stress
trauma
sepsis

Question 14

major carrier protein for IGF I

Answer 14

IGF BP3

Question 15

major determinant of hepatic IGF I synthesis

Answer 15

GH

Question 16

hypothalamic dysfunction and hypopituitarism

Answer 16

septo-optic dysplasia

Question 17

critical for determining the devlt and dcommited functin of anterior pit hormones

Answer 17

pit 1

prop 1

Question 18

result in combined GH,PRL, TSH, gonadotropin deficiency

Answer 18

prop 1 mutation

Question 19

mutation that result in ACTH deficiency

Answer 19

TPIT

Question 20

Kallman syndrome is GnRH deficiency assoc with

Answer 20

anosmia/hyposmia

Question 21

char by mental retardn, renal, dactyly, obesity problems

Answer 21

bardet-beidl

Question 22

cause hyperphagia, obesity and hypogonadism

Answer 22

leptin and lep receptor mutation

Question 23

syndrome associated with hypo GONADOtropic hypogonadism, hyperphagia-obesity, muscle hypotonia, Adult onset DM

Answer 23

prader willi syndrome

Question 24

in cranial irradiaton, 2/3 hormone insufficiency develops after median dose of?

Answer 24

50 Gy

Question 25

acquired. occurs often in postpartum women, hyperprolactemia; mass

Answer 25

lymphocytic hypophysitis

Question 26

acute intrapituitary hemorrhagic vascular events

Answer 26

apoplexy (sheehan’s in pregnant)

Question 27

acute symptoms of apoplexy includes

Answer 27

severe headache with signs of meningeal irritation

Question 28

associated with intracranial hypertension; silent involution –> fills up by CSF; incidental finding on MRI

Answer 28

empty sella

Question 29

this group of deficiency usually develop later in the course pf pituitary failure

Answer 29

ACTH and TSH

Question 30

lab diagnosis of pituitary deficiency

Answer 30

low tropic hormones, low target hormones!

Question 31

ACTH reserve is most reliably assessed by?

Answer 31

measuring ACTH and cortisol levels at insulin induced hypogly

Question 32

inducing hypoglycemia is contraindicated in ? for acth

Answer 32

CAD or sseizure DO