Cancer Translocations

Question 1

Burkitt Lymphoma

Age group and translocation?

Answer 1

Adolescents or young adults

t(8;14). Translocation of c-myc and heavy chain Ig. Increased expression of C-myc

Question 2

Follicular Lymphoma

Age group and translocation?

Answer 2

Adults
t (14;18) translocation of heavy chain Ig and BCL-2.
(as a note: BCL-2 inhibits apoptosis so this mutation confers a survival advantage)

Question 3

Mantle cell lymphoma

Age Group and translocation?

Answer 3

Older Males

t(11;14). Translocation of cyclin D1 and heavy chain Ig

Question 4

Acute Myelogenous Leukemia

Age Group and Translocation?

Answer 4

65 years old
Associated with Down Syndrome
t(15;17)–> this refers specifically to the M3 type of AML which is actually APL (acute promyelocytic leukemia)

Question 5

Chronic Myelogenous Leukemia

Age Group and Translocation?

Answer 5

45-85 Years old (median 64)

Philadelphia Chromosome t(9;22) BCR-ABL translocation.

Question 6

Acute Lymphoblastic Leukemia/Lymphoma (ALL)

Age Group and Translocation?

Answer 6

Less than 15 years old
Associated with Down Syndrome
t(12;21) This is actually associated with a better prognosis

Question 7

New Card

Answer 7

Nothing