Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Step Shit > Drug mechanisms > Flashcards

Drug mechanisms Flashcards

1
Q

Macrolide mechanism

A

inhibit protein synthesis by blocking translocation; bind to 23S rRNA of 50S ribosomal subunit. Bacteriostatic

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Macrolide mechanism of resistance

A

methylation of 23S rRNA binding site prevents binding of drug

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Vancomycin mechanism

A

binds to pentapeptide side chain of peptidoglycan precursor molecules, preventing formation of cross-bridges needed for functional bacterial cell wall

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Vancomycin mechanism of resistance

A

bacteria alter termini of side chains from D-ala-D-ala to D-ala-D-lactate

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Sulfa drugs mechanism

A

competitively inhibit production of folic acid by bacteria

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Fluoroquinolone mechanism

A

inhibit DNA gyrase, bacteria need to replicate DNA

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Fluoroquinolone mechanism of resistance

A

selection for mutations in gene for DNA gyrase

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

penicillin resistance mechanism

A

bacterial production of beta-lactamases that cleave the drugs

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Drugs affecting bacterial folic acid synthesis

A

sulfonamides

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Drugs acting on DNA topoisomerases

A

fluoroquinolones

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Drugs damaging bacterial DNA

A

metronidazole

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Drugs affecting mRNA synthesis

A

rifampin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Drugs affecting protein synthesis

A

Macrolides, Streptogramins, Aminoglycosides, Tetracyclines, choramphenicol, clindamycin, linezolid

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

drugs affecting 30S subunit in bacterial protein synthesis

A

Aminoglycosides (amamikacin, Gentamycin, neomycin, streptomycin, tobramycin), Tetracyclines (doxy-, mino-, tetra-)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Drugs affecting 50S Subunit in protein synthesis

A

Chloramphenicol, Clidamycin, Linezolid, Macrolides (azithromycin, clarithro-, eriythro-), Streptogramins

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Drugs affecting Cell wall synthesis

A

Glycopeptides, Penicillinase-sensitive penicillins, Penicillinase resistance penicillins, antipseudomonals, cephalosporins (I-IV), carbapenams, monobactams

17
Q

Drugs affecting bacterial peptidoglycan synthesis

A

Glycopeptides – Bacitracin, Vancomycin

18
Q

Drugs affecting peptidoglylcan cross-linking

A

penicillinase-sensitive and penicillinase-resistant penicillins, antipseudomonals, cephalosporins (I-IV), carbapenems, monobactams

Step Shit (14 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions