Path 2 - MEN, pit, parathy

Question 1

does MEN affect younger or older

Answer 1

younger

Question 2

what are the 3 P’s of MEN1

Answer 2

pancreatic tumor
pituitary adenoma
parathyroid hyperplasia

Question 3

what thyroid tumor is involved in MEN2 and FMTC

Answer 3

familiar medullary thyroid carcinoma

Question 4

what are the MEN2A tumors

Answer 4

parathy hyperplasia
medullary thyroid carcinoma
pheochromocytoma

Question 5

how are MEN2A and 2B different

Answer 5

2B = no parathy hyperpl, + mucosal neuroma, + marfanoid

Question 6

the only tumor in FMTC

Answer 6

isolated familial medullary thyroid carcinoma

Question 7

what gene is wrong in MEN2

Answer 7

RET

Question 8

what gene is wrong in MEN1

Answer 8

MEN1

Question 9

where does pheochromo arise from

Answer 9

chromaffin cells of adrenal medulla

Question 10

what metabolite helps detect pheochomo

Answer 10

metanephrine

Question 11

clinical presentation of pheochromo

Answer 11

severe episodic HTN or feelings of doom

Question 12

what are some ex of pheo syndromes

Answer 12

MEN2A/B, NF1, VHL

Question 13

sporadic case = early or later in life

Answer 13

later in life

Question 14

color of pheochromo

Answer 14

brown - displace cortex

Question 15

pheo has lots or little cytoplasm

Answer 15

lots of cyto

Question 16

when do functional antpit tumors present

Answer 16

early

Question 17

what is most common functional AP adenoma

Answer 17

prolactinoma

Question 18

second most common func AP adenoma

Answer 18

GH cell adenoma

Question 19

GH adenoma in kids =

Answer 19

gigantism

Question 20

GH adenoma in adults

Answer 20

acromegaly

Question 21

symptoms of adult acromegaly

Answer 21

gonad dysfunction
DM
muscle weakness
HTN
GI cancer

Question 22

tx of GH cell adenoma

Answer 22

resection, drugs

Question 23

ACTH adenoma causes

Answer 23

cushing disease

Question 24

signs of cushing syndrome

Answer 24

central obesity, moon face, atrophy, hair, HTN, osteo, gluc tolerance, striae

Question 25

are pituitary carcinomas common

Answer 25

NO

Question 26

TSH adenoma =>

Answer 26

hyperthyroidism

Question 27

what is pan-hypopituitarism

Answer 27

hormonal insufficiency (low endo signal, pallow, amenorr, lose pubes)

Question 28

cause of pan-hypo

Answer 28

pituitary apoplexy, iscehmic necrosis (sheehan)

Question 29

SON =

Answer 29

ADH

Question 30

PVN =

Answer 30

oxytocin

Question 31

etiology of SIADH

Answer 31

ectopic (cancer) or injury

Question 32

brain manifestations of SIADH

Answer 32

cerebral edema, neuro dysfunction

Question 33

hypopituit causing tumor

Answer 33

craniopharyngioma

Question 34

effect of cranioph on kids

Answer 34

growth retardation

Question 35

effect of cranioph on adults

Answer 35

mass effects => DI

Question 36

how does malignancy cause hypercalcemia

Answer 36

secretion of RANKL
PTHrP secretion

Question 37

proprtion of fat to function in parathy

Answer 37

50/50

Question 38

what is tertiary hyperparathy

Answer 38

adenoma after chronic low ca => high PTH => PTH adenoma

Question 39

fat composition of PT adenoma

Answer 39

very low

Question 40

incidence of PT carinoma

Answer 40

very LOW

Question 41

what MEN syndromes is parathy hyperplasia seen in

Answer 41

MEN 1 and MEN 2A

Question 42

path characteristic of parathy hyperpl

Answer 42

hypercellular

Question 43

visceral complications of pri hyperparathy

Answer 43

metastatic calcification (kidney, vessels, soft tissue, eyes)

Question 44

T/F PT cells have basal level of PTH secretion

Answer 44

TRUE

Question 45

congenital cause of hypoparathy

Answer 45

DiGeorge