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Flashcards in 46 anti arrhythmic drugs Deck (31)
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1

cardiac arrhythmias are categorized by what?

location of origin

2

What are the 2 types of supra ventricular arrhythmias?

atrial and nodal

3

Is torsades de pointes a supraventricular or a ventricular arrhythmias?

ventricular

4

What is the goal of drug therapy for abnormal automaticity cause of arrhythmia?

reduce ectopic pacemaker activity

5

What is the goal of drug therapy for abnormal impulse conduction cause of arrhythmia?

modify conduction or refractoriness in reentry circuits

6

What drugs [decrease? but he changed to increase] phase 4 slope?

beta and Ca channel blockers

7

What drugs increase maximum diastolic potential?

adenosine

8

What drugs increase the threshold?

Na and Ca channel blockers

9

What drugs increase action potential duration?

k channel blockers

10

Drugs can abolish re-entry by what 2 mechanisms?

1. Further slowing depressed conduction (Na or Ca channel block)
2. lengthening refractory period

11

What 2 mechanisms to lengthen refractory period?

Na channel and K channel blockers

12

What is a smart drug?

state and use dependent block

13

TF- depolarization of resting membrane decreases lidocaine block?

False- increases it

14

T-F-- tachycardia increases lidocaine block?

True

15

Class I anti arrhythmic mechanism?

Na channel-slow phase 0 depolarization slow conduction

16

Class II anti arrhythmic mechanism?

beta adrenergic receptor block

17

Class III anti arrhythmic mechanism?

K channel block

18

Class IV anti arrhythmic mechanism?

Ca2+ channel block

19

Class IA, IB, IC are unbound with what rate of kinetics? and do what to the action potential?

1. Medium, fast, slow
2. prolong, shorten, minimal effect

20

Class IA drugs also block what?

K channels

21

Procainamide metabolite predisposes to what?

Action potential prolongation, EADS, arrhythmias

22

What patients should we avoid using class IC antiarrhymic drugs?

underlying structural heart disease or post-myocardial infarction

23

What class I anti-arrythmic is a IV only drug?

Lidocaine

24

What class II anti-arrythmic is a IV only drug?

esmolol

25

What class III anti-arrythmic is a IV only drug?

ibutilide

26

Which Class III anti-arrythmic drug does not need to be started in a hospital, what is unique about it? why do we start them in hospitals?

1. amiodarone- does require regular monitoring! accumulates in tissues lipid soluble
2. monitor for acute QT prolongation -torsade de pointes

27

What does dronedarone lack?

lack thyroid and pulmonary toxicity of amiodarone

28

What do Ca channel blockers do to the QRS complex?

slow rate and reduce maximal height

29

What is a strong drug to break up AV node arrhythmia?

verapamil and diltiazem

30

Adenosine activates what receptor and inhibits what?

Ik, Ica