lecture 10

Question 0

Segments and types of influenza

Answer 0

Type A and B - 8

Type C - 7

Question 1

Family of influenza

Answer 1

Orthomyxovirus

Question 2

Influenza viral type

Answer 2

(-)SSRNA

Question 3

IFL symptoms

Answer 3

Sore throat
Myalgias
Arthralgias
Prostation

Fever cough

Question 4

Peak of influenza

Answer 4

Nov to march

Question 5

What determines the viral type

And what gives the flu its viral strain

Answer 5

M1 and NP proteins

HA AND NA

Question 6

What does the M1 and NP protein do

Answer 6

M1: bund MB and RNA
NP: organizes RNA into helix

Question 7

Sources of influ
Type a
Type b
Type c

Associated with?

Answer 7

Human epidemics
a - birds
B - almost all humans but seals and ferrets

Respiratory illness
C - just humans

Question 8

Bird flu
Types that affect humans
Their names

Answer 8

H1n1 h2n2 h3n2

Question 9

What is the role of HA and NA

Answer 9

HA entry
Subunits HA1 - provided receptor binding
HA2 - helps w membrane fusion

NA - liberate new visions progeny viruses

Question 10

What is antigenic drift and shift? Details

Answer 10

Minor change

Major change

Question 11

Strains of flu 2015-2016

Answer 11

A h1n1
A h3n2
B yamagata

Question 12

3 potential mechanisms for ____ influenza strains

Answer 12

Pandemic

DAR

Question 13

What is epithelial cytotoxicity?

Answer 13

Goblet cells hyperplasia

Question 14

Uncomplicated Influenza symptoms?

Answer 14

Fever cough Myalgias

Question 15

Innate and adaptive role in clearing the flu

Answer 15

…

Question 16

Steps in developing influenza vaccine

Answer 16

Identify endemic strains for coming year
Test for high growth potential
Recombinant engineering on vaccine

Question 17

What is HIV

Answer 17

Lentivirus
Retrovirus
Oncogenes

Question 18

HIV structure (envelope and capsid)

Answer 18

Enveloped virus with important glycoproteins

Capsid has 2 strands of RNA and protein reverse transcriptase

Question 19

Primary and secondary targets for HIV

Answer 19

CD4

Monocytes macrophages epithelial cells and CNS cells

Question 20

HIV cellular and anatomical reservoirs

Answer 20

Macrophages and dendritic cells

Anatomical: CNS male genital tract GI tract and lymphoid tissues

Question 21

Info about CCR5

Answer 21

….

Question 22

Info about CXR4

Answer 22

…

Question 23

What chromosome is CCR5 encoded on? What happens if we delete it

Answer 23

Chrom 3 and reduce chance of infection

Question 24

Factors increasing CCR5 expression

Answer 24

TB
LPS
IL10 because it stops Th1 expression

Question 25

What is the HIV infection cycle?

And gp120?

Answer 25

….

Question 26

What do we want our T cell count to be?

Answer 26

Above 200mcl

Question 27

What Indicates AIDS?

Answer 27

Cd4 count underneath 200/mm3

Question 28

Symptoms of late stage AIDS

Answer 28

Swelling in lymph nodes in neck groin and armpits
Sores
Purple blotches

Question 29

Natural resistance can be seen in diff ways and its measured by zero status

Answer 29

1. Remain seroneg after exposure
2. Remain positive and never develop AIDS
3. Remain positive and be asymptomatic for a long time