Rx Onc Drugs Flashcards

You may prefer our related Brainscape-certified flashcards:
1
Q

Microtubule inhibitors

A

Paclitaxel and other taxols
“taxing to stay polymerized”
mitotic spindle can’t break down
used for advanced ovarian and metastatic breast cancer

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Vinca Alkaloids

A

Vinblastine, Vincristine

Prevent mitotic spindle formation

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

decr NT synth

A

MTX, 5-FU - Thymidine
6-MP - denovo purine
Hydroxyurea - i. RNt reductase

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Inhib. at level of DNA

A
Alkylating agents, cisplatin 
bleomycin
dactinomycin, docorubicin
etoposide
irinotecan
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Alkylating agents, Cisplatin

A

cross-linking of DNA “-ustine”

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Bleomycin

A

DNA strand breaking

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Dactinomycin, doxorubicin

A

DNA intercalators

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Etoposide

A

inhibits topoisomerase II

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Irinotecan

A

inhibits topoisomerase I

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Vinblastine

A

both Hodgkin and Non-Hodgkin lymphoma and many solid tumors

How well did you know this?
1
Not at all
2
3
4
5
Perfectly