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USMLE Step Uno > Rx Onc Drugs > Flashcards

Rx Onc Drugs Flashcards

1
Q

Microtubule inhibitors

A

Paclitaxel and other taxols
“taxing to stay polymerized”
mitotic spindle can’t break down
used for advanced ovarian and metastatic breast cancer

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2
Q

Vinca Alkaloids

A

Vinblastine, Vincristine

Prevent mitotic spindle formation

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3
Q

decr NT synth

A

MTX, 5-FU - Thymidine
6-MP - denovo purine
Hydroxyurea - i. RNt reductase

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4
Q

Inhib. at level of DNA

A 
Alkylating agents, cisplatin 
bleomycin
dactinomycin, docorubicin
etoposide
irinotecan
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5
Q

Alkylating agents, Cisplatin

A

cross-linking of DNA “-ustine”

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6
Q

Bleomycin

A

DNA strand breaking

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7
Q

Dactinomycin, doxorubicin

A

DNA intercalators

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8
Q

Etoposide

A

inhibits topoisomerase II

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9
Q

Irinotecan

A

inhibits topoisomerase I

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10
Q

Vinblastine

A

both Hodgkin and Non-Hodgkin lymphoma and many solid tumors

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USMLE Step Uno (8 decks)

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