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IMMUNOLOGY: CMOD-Week 1 > (04) Complement Cascade Inhibitors > Flashcards

(04) Complement Cascade Inhibitors Flashcards

1
Q

C1INH

A

Inhibits C1

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2
Q

C4BP

A

Breaks apart CLASSICAL C3 convertase

- proteolysis via Factor I

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3
Q

Factor H

A

C3b proteolysis causing iC3b formation

*Inhibition of ALTERNATIVE C3 convertase

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4
Q

Factor I

A

Protease cleaving C3b and C4b

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5
Q

DAF

A

C3 convertase inhibition

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6
Q

MCP

A

C3 convertase inhibition
C3b proteolysis

  • Both via Factor I
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7
Q

CD59

A

Prevents C9 from binding C5-8

*Inhibits MAC formation

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8
Q

Factor P (P)

A

Stabilizes alternative C3 convertase

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IMMUNOLOGY: CMOD-Week 1 (10 decks)

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