(04) Complment Receptors!!!

Question 1

CR1

• Specificity
• Function
• Cell Types

Answer 1

Specificity:
- C3b, C4bi

Function:

• Promotes C3b and C4b decay
• Stimulates Erythrocyte transport of immune complexes

Cell Types:

• Erythrocytes
• Macrophages/ Monocytes
• Nuetrophils
• B-cell
• FDC

Question 2

CR2 (CD21)

• Specificity
• Function
• Cell Types

Answer 2

Specificity:
- C3d, iC3b, C3dg (EBV)

Function:

• Part of B-cell Co-Receptor
• Epstien Barr Virus Receptor

Cell Types:

• B cells
• FDC

Question 3

CR3 (Mac-1)(CD11b/CD18)

• Specificity
• Function
• Cell Types

Answer 3

Specificity:
- iC3b

Function:
- Stimulates Phagocytosis

Cell Types:

• Macrophages/Monocytes
• Neutrophils
• FDC

Question 4

CR4 (gp150, 95)(CD11c/18)

• Specificity
• Function
• Cell Types

Answer 4

Specificity:
- iC3b

Function:
- Stimulates Phagocytosis

Cell Types:

• Macrophages/ Monocytes
• Neutrophils
• Dendritic cells

Question 5

C5a receptor

• Specificity
• Function
• Cell Types

Answer 5

Specificity:
- C5a

Function:
- Binding of C5a activates G protein

Cell Types:

• Endothelial Cells
• Mast Cells
• Phagocytes

Question 6

C3a receptor

• Specificity
• Function
• Cell Types

Answer 6

Specificity:
- C3a

Function:
- Binding C3a activates G-protein

Cell Types:

• Endothelial Cells
• Mast Cells
• Phagocytes