#47: Lipid Lowering Agents

Question 1

Action of Lipid Lowering Drugs

Answer 1

Lower serum levels of cholesterol and lipids

Prevent of CAD

Question 2

Drugs to Tx Hyperlipidemia

Answer 2

Bile Acid Sequestrants
HMG-CoA Inhibitors
Fibrates
Niacin
Cholesterol Absorption Inhibitors

Question 3

Bile Acid Sequestrants Action

Answer 3

Binds bile acids in the intestine, allows excretion in feces instead of reabsorption, causes cholesterol to be iodized in the liver, and serum cholesterol levels to fall

Question 4

Bile Acid Sequestrants Indications

Answer 4

Reduces elevated serum cholesterol in patients with primary hypercholesterolemia, pruritus associated with partial biliary obstruction

Question 5

Bile Acid Sequestrants Pharmokinetics

Answer 5

Not absorbed systemically

Excreted in the feces

Question 6

Bile Acid Sequestrants Contraindications

Answer 6

Allergy
Complete biliary obstruction
Abnormal intestinal function
Pregnancy + Lactation

Question 7

Bile Acid Sequestrants Adverse Effects

Answer 7

GI Irritation
Increased bleeding times
Vit A + E Deficincies

Question 8

Bile Acid Sequestrants Drug Interactions

Answer 8

Malabsorption of fat-soluble vitamins

Thiazide diuretics, digoxin, warfarin, thyroid hormones, and corticosteroids