Lecture 2

Question 1

What components are required to generate naive T lymphocytes?

Answer 1

1. pluripotent stem cell (CD34+) differentiates into lymphoid progenitor cells
2. IL-1,2,6,7 combine from dendritic cells to form the naive T cell
3. naive T cell can then form CD4+ Th or CD8+ Tc

Question 2

What is the process and components that are required to generate naive B cells?

Answer 2

1. Pluripotent stem cell (CD34+)
2. lymphoid progenitor cell combines with IL-1,6,7 from stromal cells
3. Produces B lymphocyte

Question 3

How does proliferation differ between a fetus and a newborn?

Answer 3

• fetus have proliferation process in the liver.

- after birth the proliferative process occurs in the bone marrow.

Question 4

What areas of the body have minimal to no amount of lymphocytes circulating?

Answer 4

1. eye
2. brain
3. testicles.

Question 5

In response to chemokines, lymphocytes are able to hone in to a certain tissue and transmigrate. What is the process by which they do this?

Answer 5

1. diapedesis