Tumor suppressor genes Flashcards by Elaine Zhou | Brainscape

Q

APC

A

Colorectal cancer (FAP)

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Q

BRCA1/BRCA2

A

DNA repair protein

Breast and ovarian cancer

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Q

CDKN2A

A

p16, blocks G1 –> S

Melanoma, pancreatic cancer

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Q

DCC

A

Deleted in colon cancer

Colon cancer

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Q

DPC4/SMAD4

A

Deleted in pancreatic cancer

Pancreatic cancer

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Q

MEN1

A

Menin

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Q

NF Type 1

A

RAS GTPase activating protein

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Q

NF2

A

Merlin (schwannomin) protein

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Q

PTEN

A

Breast cancer, prostate cancer, endometrial cancer

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Q

Rb

A

Inhibits E2F; blocks G1 –> S phase

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Q

TP53

A

Li-faumeni syndrome

p53 actives p21, blcoks G1–> S phase

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Q

TSC1

A

Hamartin protein

Tuberous sclerosis

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Q

TSC2

A

Tuberin protein

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Q

VHL

A

inhibits hypoxia inducivle factor 1a

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Q

WT1/WT2

A

Wilms Tumor (nephroblastoma)

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