Topic 25 - Hematopoiesis: Granulocyte cell line Flashcards
Granuleres:
occurance and origin
- Occurs in the midportion of hematopoietic compartment (away from vascular sinuses)
- Originating from bipotent CFU-GM (colony-forming units-granulocyte-monocyte).
Granuleres: produces
neutrophil and monocyte progenitor cells.
What are the stages and how long do they take?
5-7 days
- Myoblast
- Promyelocyte
- Myelocyte
- Metamyelocyte
- Band form
- Mature form
Myoblast
ovoid or spherical cell with spherical euchromatic nucleus. Stains light blue.
Promyelocyte
larger, similar nucleus, increased cytoplasm with azurophilic granules.
Myelocyte
spherical to slightly indented nucleus, some chromatin condensation, specific and azurophilic granules. Specific granules indicate the type of granulocyte that will form.
Metamyeleocyte
indented and kidney-shaped heterochromatic nucleus. Specific granules stain specific colours. No more division.
Band form
further nuclear indentation, producing C-, S-, or V-shaped nuclei.
Mature form
marked segmented nuclei and specific granules.
Compartments of granulocytic cells:
- Proliferative (mitotic): myeloblasts, promyelocytes, and myelocytes.
- Maturative (post mitotic): metamyelocytes and band form neutrophils.
- Reserve (storage): mature neutrophils.
Compartments of blood neutrophils:
- circulating (6-14 hours) marginating
- Blood neutrophil pool is replaced twice daily.
Neutrophil production is similar to:
• eosinophils, basophils, and monocytes.
monocytopoiesis
what is it and origin
formation of monocytes
Originate from CFU-M (folony-forming unit-monocytes), common neutrophil ancestor
stages
• Monoblast
• Promonocyte: azurophilic granules
• Monocyte: final shape and size of nucleus.
-Monocytes reside in bloodstream from 24 hours, then enter CT as macrophages.
-Their development is still not fully understood.
