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Heme/Lymph 2 > Hubbard > Flashcards

Hubbard Flashcards

1
Q

TTP - treatment

A

Plasmapheresis

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2
Q

vWD presents as ____

A

Mucocutaneous bleeding

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3
Q

Treatment for vWD

A

Cryoprecipitate (vWF) + DDAVP (release vWF)

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4
Q

Vitamin K deficiency - labs

A

Prolonged PT, deficient factors 2, 7, 9, 10, C, S

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5
Q

Treatment for vitamin K deficiency

A

Normal liver fxn – vitamin K supplements

Liver disease or acute hemorrhage – FFP

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6
Q

Hereditary hemorrhagic telangiectasia - gene deficiency

A

Endoglin (CD 105)

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7
Q

Function of antithrombin 3

A

Serine protease - inhibits thrombin activation

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8
Q

AT3 requires what?

A

Heparin

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9
Q

AT3 deficiency causes increased risk of _____

A

Clotting (via thrombin activation)

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10
Q

AT3 deficiency - presentation

A

Recurrent LE thrombophlebitis, DVT, leg ulcers, PE

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11
Q

AT3 deficiency - treatment

Refractory?

A

Anticoagulants (heparin)

AT3 replacement

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12
Q

Protein C/S deficiency - treatment

A

Warfarin

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13
Q

Factor V Leiden - risk?

Treatment?

A

Thromboembolism

No episodes = monitor, etc.

Prior episode(s) = lifelong anticoagulation

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14
Q

Prothrombin 20210

Risk?

A

G-A mutation, causing increased prothrombin activity

Thrombosis

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15
Q

Common occurrences w/ antiphospholipid syndrome

A
  • Thromboembolism
  • Miscarriage
  • Thrombocytopenia
  • Cerebral ischemia/stroke
  • UBOs on MRI
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16
Q

Diagnosis of antiphospholipid syndrome (3)

A
  • Prolonged PTT
  • No correction using normal plasma
  • Neutralization w/ excess phospholipid
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17
Q

Specific diagnostic test for antiphospholipid syndrome

A

Dilute Russell viper venom time (DRVVT)

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18
Q

Treatment for antiphospholipid syndrome

A

Hx of thromboembolism –> lifelong anticoagulation

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19
Q

ITP - treatment

A

Prednisone

20
Q

Reactive leukocytosis, thrombocytopenia, prolonged PT and PTT, no RBC fragments on smear

How to diagnose?

A

DIC - from infection

Dx = D-dimer level

21
Q

DIC treatment

A

Treat the cause, FFP, cryoprecipitate, platelet transfusions

22
Q

Hyaline thrombi that occlude the capillaries of basically every organ

A

TTP

23
Q

Patient on prolonged antibiotics, PT starts to get longer

A

Vitamin K deficiency - no microbial production

24
Q

Connective tissue disease, prolonged PTT that doesn’t correct, valvular heart disease, recurrent stroke, thrombocytopenia

A

Antiphospholipid syndrome

25
Q

Superficial venous thrombosis - risk?

A

DVT, PE

26
Q

Oral contraceptives - risk (when combined w/ other disorders)?

A

Thrombosis

27
Q

Erythromelalgia - treatment

A

Aspirin

28
Q

SPEP gamma spike w/ hump after

Treatment?

A

MGUS

NO treatment, just monitor

29
Q

Solitary plasmacytoma - treatment

A

Local radiation

30
Q

Multiple myeloma - diagnosis

What not to do?

A

Skeletal survey

NOT A BONE SCAN

31
Q

Multiple myeloma - treatment

A

Thalidomide/lenolidamide + dexamethasone

32
Q

Sausage-linking of fundoscopic veins

A

Waldenstrom’s hyperviscosity

33
Q

Waldenstrom’s - treatment

A

Plasmapheresis, hydration, bisphosphonate

34
Q

Fat pad = green birefringence on congo red

A

Amyloidosis

35
Q

Joint pain, infections, anemia, bleeding, pedal edema

Multinucleate plasma cells w/ Dutcher bodies in BM

A

Amyloidosis (AL - light chain)

36
Q

Temporal muscle wasting, chronic diarrhea, pre-renal disease, malabsorption

Treatment?

A

Alpha heavy chain disease

Antibiotics

37
Q

Aplastic anemia - treatment

A

Cyclosporin + anti-thymocyte globulin

38
Q

Diffuse rash, hemolytic anemia, elevated ESR, Gimsa stain

Classic finding?

A

Babesiosis

Maltese cross

39
Q

Oral contraceptives + Factor V Leiden

A

35x increased risk of hypercoaguability

40
Q

Hydroxyurea

A

Increased HbF in sickle cell

41
Q

Acute chest syndrome - treatment

A

Transfusion

42
Q

Treatment for PCV and ET

A

IFN-alpha, phlebotomy

43
Q

Black water fever

A

RBC burst into blood (malaria complication) - hemoglobinuria and bilirubinuria (direct and indirect)

44
Q

Neuropathy, HSM, endocrine issue, M spike, skin and skeletal lesions

A

POEMS syndrome - osteosclerotic myeloma

45
Q

Male, eczema, thrombocytopenia, bloody diarrhea, recurrent infections

A

Wiskott-Aldrich (congenital thrombocytopenia)

Heme/Lymph 2 (16 decks)

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