IBD drugs

Question 1

Anti inflammatory drugs

Answer 1

SALA!
Balsalazide, Medsalamine, olsalazine, Sulfasalazine

1st line for mild-moderate UC, not effective for crohn’s

Not absorbed in stomach

Question 2

Antiinflammatory drug that has side effects

Answer 2

Sulfasalazine because it’s a sulfadrug. hypersensitivity, decreased folate absorption

Question 3

Immunosuppressive drugs. 2 classes
Corticosteroids
Antimetabolites

Answer 3

Corticosteroids
BUDESONIDE, PREDNISONE, PREDNISOLONE

Antimetabolites
AZATHIOPRINE, 6-MERCAPTOPURINE, METHOTREXATE

Question 4

Corticosteroid uses

Answer 4

moderate to severe active IBD

Budesonide has less systemic effects

Question 5

Antimetabolites uses

Answer 5

induction and maintenance of remission of UC and CD

Question 6

Monoclonal antibody drugs (2)

Answer 6

INFLIXIMAB, NATALIZUMAB

Question 7

INFLIXIMAB MOA

Answer 7

against TNF-alpha

***Infliximab can lead to symptomatic improvement (60%) and remission (30%) in patients with moderately severe CD – SIGNIFICANT

Question 8

NATALIZUMAB MOA

Answer 8

Anti-alpha 4 subunit of integrin? used for MS and Crohn’s

can reactivate JC virus