vulva and vagina Flashcards
characteristic histological features of HSV infection (2)
intranuclear inclusions (Cowdry bodies) and multinucleate giant cells
HPV types assoc with genital warts
6, 11 (low risk)
physical exam findings of lichen sclerosis
leukoplakia, parchment-like epidermis
lichen sclerosis has increased risk for–
squamous cell carcinoma
physical exam findings of lichen simplex chronicus
leukoplakia, thick/leathery epidermis
2 “types” of vuvlar squamous cell carcinoma
HPV related (16,18) non-HPV related (lichen sclerosis, p53)
type of vulvar SCC associated with lichen sclerosis
non-HPV associated
what is extramammary Paget’s disease
malignant epithelial cells in the epidermis of the vulva that presents as an erythematous/itchy/uclerated skin lesion
what is different between Paget’s of the nipple vs vulva?
nipple- assoc with underlying malignancy
vuvla- no underlying malignancy
how is Paget’s of vulva differentiated from melanoma
Pagets: PAS+, keratin+
melanoma: S100+
estrogen is responsible for ___ in vaginal epithelial cells
glycogenation
effects on DES daughters (4)
vaginal adenosis, clear cell carcinoma, abnormalities of smooth muscle= infertility and pregnancy loss
what is adenosis?
persistence of columnar epithelium in the upper 2/3 of the vagina, related to DES exposure
clear cell adenocarcinoma
vaginal malignancy associated with proliferations of glands with clear cytoplasm in upper 1/3 of vaginal, related to DES exposure
characteristic tissue/cell for embryonal rhabdomyosarcoma
tissue- immature skeletal muscle
cell- rhabdomyoblast
