Neurobiology of Abnormal Mood Flashcards
What are your appetitive/approach systems
function to mediate seeking and approach behaviour i.e. pleasure
What are your aversive/defensive systems
promote survival i.e. avoid in response to fear/pain
What neurotransmitter is involved in appetitive/approach systems
dopamine
what neurotransmitter is involved in aversive/defense systems
serotonin
list the parts of the brain involved in appetitive/approach systems
ventral and dorsal striatum
amygdala
anterior cingulate
orbitofrontal cortex
Name the partf of the brain involved in aversive/defense systems
amygdala
hippocampus
hypothalamus
periaqueductal gray matter
What happens when the appetitve/approach system is dysfunctioning
depression or mania can occur
depression - difficulty identifying rewarding stimuli results in decreases contact with rewards
mania- neutral stimuli become rewarding
what gender is depression more common in
women
Describe the changes that occur in the hypthalmic-pituitary-adrenal axis in depression
increased ACTH increased cortisol elevated cortisol in urine increased CRH in CSF enlarged adrenals
half of pts fail to suppress cortisol following dexamethasone
Decribe the changes that happen in the thyroid axis in major depression
increased TRH in CSF can occur
What are the key regions implicated in mood disorders
prefrontal cortex
hippocampus
amygdala
anterior cingulate cortex
what happens to the hippocampus in depression
it becomes atrophied
What is seen on imaging in bipolar disorder
reduced grey matter in anterior cingulate
