Interstitial and Cystic Kidney Disease Flashcards
What is the pathogenesis of Cystic Kidney disease?
Devt from renal tubules
lose att to nephron segments
abn cellular diff and prolif on Epi
Remodeling of ECM
How is ADPKD diagnosed?
Through imaging
- renal US
- IVP
- CT/MRI
What are the conditions associated with ADPKD?
IC Aneurisms PCLD HTN Cardiac Complications Renal complications
Who should be screened for Intracranial aneurisms?
anyone with ADPKD
young
Have preserved kidney function
FHx of IC aneurisms
What kidney neoplasm is associated with Tuberous sclerosis?
Angiomyolipoma
What kidney neoplasm is associated with VHL?
RCC
What are the conditions associated with Medullary Sponge Kidney?
Nephrolithiasis -renal colic -loin pain -small stones Hematuria UTI
What is seen on patholgy in Medullary Sponge Kidney?
Irregular enlargement of the medullary and inner papillary portions of collectig ducts
What is the presentation of Acute intersitial Nephritis?
Elevation of BUN and Creatinine
Abn UA -Eosinophelia
Renal biopsy is Gold Standard
What is seen on patholgy in Acute Intersitial Nephritis?
inflammatory cells in renal intersititium
-lymphocytes
-Polymorphonuclear granulocyutes(eosinophils)
Edema
Glom and BV spared
What are the causes of Drug induced Acute intersitial Nephritis?
Abtx
NSAIDS
Diuretics
Misc
What is the clinica presentation of Chronic Intersitial Nephritis?
Slowly progressive chronic renal insufficiency
UA normal or sterile pyuria
Mild proteinuria
HTN and Anemia in adv disease
