Path Eye Flashcards

- Compare and contrast acute vs. chronic glaucoma (open angle vs. closed angle) - Define the following degenerative conditions of the eye: Arcus Senilis, Pterygium, Pinguecula, Macular degeneration (wet vs. dry), Cataracts - Describe the pathologic manifestations of diabetic retinopathy. - List the common causes of central retinal artery and vein occlusion. - Describe the clinicopathologic features of 2 common tumors of the eye (melanoma and retinoblastoma) - Define chalazion

1
Q

Viruses that can cause conjunctivitis

A

adenovirus and Herpes simplex

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2
Q

bacteria that can cause conjunctivitis

A

Opthalmia noenaturum

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3
Q

neoplasms that can cause conjunctivitis

A

Squamus cell carcinoma, melanoma

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4
Q

small raised pale yellow-tan nodule, usually nasal

A

pinguecula

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5
Q

triangular vascularized growth onto cornea from nasal limbus

A

pterygium

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6
Q

most common type of glaucoma

A

open angle

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7
Q

glaucoma more common in blacks

A

open angle

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8
Q

cause of close angle glaucoma

A

physical obstruction of outflow tract by peripherial iris, causing increased intraocular pressure

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9
Q

sx of closed angle glaucoma

A

pain, redness,photophobia, decreased vision, fixed, mid-dilated pupil

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10
Q

what can trigger sx in closed angle glaucoma

A

being in a dark room for a long time

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11
Q

sx of open angle glaucoma

A

arcuate visual field loss

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12
Q

types of cataracts

A

nuclear, cortical, or subcapsular

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13
Q

causes of adult cataracts

A

sun exposure, diabetes, steroids

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14
Q

causes of congenital cataracts

A

rubella, CMV

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15
Q

vascular causes of retainopathy

A

diabetes, hypertension, vessel occulsion

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16
Q

worse form of macular degeneration

A

wet

17
Q

most common cause of macular degeneration

A

dry

18
Q

drusen on a thick, possibly calcified bruch’s membrane is..

A

dry macular degeneration

19
Q

subretinal choroidal neovascular membrane breaks through bruche’s membrane - causing hemorrage and scar

A

wet macular degeneration

20
Q

causes os optic disc edema

A

malignant hypertension, optic neuropathy, elevated ICP

21
Q

histopathologic signs of optic disc edema

A

elevation of optic disc, displacement of retina at disc margin, neerve fiber layer menorrhages at disc margin, cotton wool microinfarcts

22
Q

mutation causing retinoblastoma

A

RB gene on 13q14 (both alleles need be mutated)

23
Q

type of gene RB is

A

tumor suppressor

24
Q

clinical features of retinoblastoma

A

white pupil, strabismus

25
Q

most common secondary tumor wound in germline retinoblastoma

A

osteosarcoma

26
Q

histology of retinoblastoma

A

rosettes, fleurette, pseudorosette

27
Q

adverse prognstic findings

A

invasion into choroid and/or optic nerve, extraocular extension, diffuse and/or growth anterior to equator

28
Q

most common primary eye malignancy in adults

A

melanoma

29
Q

histology of eye melanoma

A

spindle cells, epitheliloid cells, necrosis

30
Q

adverse prognosis in eye melanoma

A

extraocular extension, large tumor, eppitheloid type, closed loop patterns, metastatses

31
Q

most common sites of melamona mets

A

liver, lung, brain, bone, GI