5

Question 1

what is the most common amino acid substitution in mutated OPRM-1 gene that leads to increased risk of alcohol relapse?

Answer 1

arginine –> aspartic acid

Question 2

how long can Etg detect alcohol for?

Answer 2

4-5 days

Question 3

which gene involved with cannabis use disorder?

Answer 3

CNR1

Question 4

CIWA score greater than what requires inpatient detox?

Answer 4

15

Question 5

short acting or long acting benzos leads to higher risk of delirium?

Answer 5

short acting

Question 6

which drug can cause discoloration of the nose?

Answer 6

inhalants (caustic burns)

Question 7

what gene associated with increased nicotine clearance (and therefore more cigarettes)?

Answer 7

CYP2A6*1B

Question 8

which genes associated with decreased nicotine clearance (and therefore less cigarettes)

Answer 8

CYP2A6*9 and *10

Question 9

how do benzos engage with GABA receptor?

Answer 9

bind to GABA-A receptor subunit –> change in conformation –> increasing receptor’s affinity for available GABA

Question 10

half life and duration of nicotine

Answer 10

half life: 2 hours

duration: 6-8 hours

Question 11

do men or women metabolize nicotine faster?

Answer 11

women

Question 12

which NT is most impacted by meth use?

Answer 12

dopamine

Question 13

which gene associated with increased risk of smoking and interaction with pharmacotherapy in smokers?

Answer 13

CHRNA5

Question 14

can electroacupuncture help alleviate opioid withdrawal symptoms?

Answer 14

yes

Question 15

venlafaxine can be false positive for

Answer 15

PCP

Question 16

which drug associated with hypertensive nephrosclerosis

Answer 16

cocaine

Question 17

which opioid is considered gold standard for pain control in terminally ill and why?

Answer 17

morphine

efficacy, minimal accumulation of harmful metabolites, administration routes

Question 18

are there differences at six month mark post detox for alcohol services in people who went to inpatient vs outpatient detox?

Answer 18

no

Question 19

which use disorder is not considered a risk factor for sedative misuse?

Answer 19

marijuana use disorder

Question 20

why is menthol added to cigarettes?

Answer 20

anesthetic activity to mitigate harsh sensation of smoking

Question 21

what are the questions of AUDIT-C?

Answer 21

1) how often do you have a drink?

2) how many standard drinks do you drink in a typical day?

3) how often do you have 6 or more drinks in an occasion?

Question 22

AUDIT-C scoring

Answer 22

≥3 = positive for women
≥4 = positive for men
≥7 = alcohol dependence

Question 23

does altered perception of time happen in MDMA?

Answer 23

yes

Question 24

LAAM no longer used in opioid treatment because

Answer 24

of risk of torsades de pointes

Question 25

how does stress affect dopamine

Answer 25

stress--> glucocorticoids --> dopamine activation --> drug seeking

Question 26

is bupe safe for breastfeeding?

Answer 26

yes! poor bioavailability in infants

Question 27

how does bupe compare to methadone in pregnancy?

Answer 27

- decreased risks preterm birth - greater birth weight - larger head circumference no greater harms

Question 28

cannabis most prevalent in which continent?

Answer 28

north america

Question 29

cannabis more prevalent in urban or rural?

Answer 29

urban pop

Question 30

CIWA scores of what suggest severe withdrawal

Answer 30

20

Question 31

how do caffeinated beverages and sodas influence NRT absorption

Answer 31

acidic drinks like caffeine and soda ionize nicotine --:> decrease oral absorption

Question 32

GHB primarily metabolized in the

Answer 32

liver

Question 33

GHB half life

Answer 33

30-60 min

Question 34

GHB can be detected in urine up to

Answer 34

24 hours