5. Antimicrobials Flashcards
(31 cards)
Which classes target PBP?
Beta-lactams: penicillins and cephems
Drugs thar target cell wall are bactericidal or bacteriostatic?
-cidal
Drug that is effective against MRSA and administered via IV?
Vancomycin
What does vancomycin target?
D-ala: D-ala of pentapeptide
Drug that inhibits protein synthesis that needs to be administered via IV?
Aminoglycoside
What is the MLS group and its target?
Macrolide-Lincosamide-Streptogramin
50S subunit
Drug from macrolide class?
Erythromycin
Drug from lincosamide class?
Clindamycin
3 aminoglycosides?
- Gentamicin
- Tobramycin
- Amikacin
Aminoglycoside spectrum?
AEROBIC G- (primarily gnb)
2 classes that target the 30S subunit?
Aminoglycosides, tetracyclines
TAG of CLEAN TAG
Drug that is known as a urinary tract disinfectant?
Nitrofurantoin
Drug with a common trade name called “Flagyl”?
Metronidazole
Why is vancomycin useful for MRSA but not VRSA?
Binds D-ala:D-ala, but VRSA has D-ala:D-lac
Drug that is a folate pathway inhibitor?
SxT
Class of drugs that targets DNA gyrase?
Fluoroquinolones - Ciprofloxacin
Toxic effects of chloramphenicol? Benefits?
Toxic - reversible bone marrow depression, aplastic anemia, gray baby syndrome
Crosses BBB = good for meningitis
2 classes of drugs that are teratogens?
- tetracyclines
- quinolones/fluoroquinolones
Drug that use useful against flagellated parasites?
Metronidazole (Flagyl)
Anti-MRSA cephem?
Ceftaroline - can bind altered PBP
Antibiotics against AEROBIC GRAM-NEG?
Aminoglycosides (gentamicin, tobramycin, amikacin)
Why are enterococci intrinsically resistant to SxT?
They use pre-formed folate
Why shouldn’t PABA and thymidine be used in AST media?
Give false R
Antibiotic that crosses BBB
Chloramphenicol
