5: Biological Effects Flashcards

(55 cards)

1
Q

What is the annual background dose of radiation that Canadians receive?

A

1.2 - 3.2 mSv

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

What is the radioisotope that is found in ALL living creatures?

A

Carbon-14

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

How is carbon-14 formed?

A

Cosmic rays interacting with the atmosphere

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

What are somatic effects?

A

Effects experienced by exposed individual (other than reproductive cells)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

What are genetic effects?

A

Passed from parent to child causes by mutations in sperm/egg cells

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

What is acute exposure?

A

Exposure to a large dose in a short amount of time

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

What is chronic exposure?

A

Irradiation over long period of time at lower intensity levels

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

What are short term/prompt somatic effects?

A

Evident short time after exposure (hours, days, weeks)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

What are long term/delayed effects?

A

Don’t become apparent until years, decades or generations after exposure

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

What are stochastic effects?

A

Associated with chronic exposure with no known minimum threshold.

(Show up years after exposure, increased levels more likely, do not affect severity/effect.)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

What are non-stochastic effects?

A

Below a known threshold effects do not occur, appear in cases of high exposure levels and become more severe as exposure increases.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

What is the ratio of red to white cells?

A

600:1

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Red blood cells carry oxygen where?

A

Carry oxygen to respiratory organs and collect carbon dioxide to bring back to respiratory organs

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

White blood cells combat infection, but too many cause what?

A

Leukaemia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Alpha particles and gamma rays have same amount of what?

A

Energy

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

What do alpha particles do inside the body?

A

Deposit all of its energy in very small volume of tissue.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

What do gamma rays do inside the body?

A

Spread energy over larger volume.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

Alpha particles are approximately how much bigger than Beta particles?

A

7000x bigger

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

Who is most affected by radiation?

A

Fetus/embryo

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

Why are children more affected by radiation?

A

They’re growing, so more cells are dividing and there’s a greater opportunity to disrupt the process.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

What kind of radiation are burns caused by?

A

Localized acuren exposure to high levels.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
22
Q

Radiation sickness is from what kind of exposure?

A

Acute exposure.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
23
Q

What happens when one gets radiation sickness?

A

Entire body absorbs a dose of at least 1 Gy.
(6+ Gy to whole body are not treatable - often lead to death 2 days to several weeks after)

Early symptoms: nausea/vomiting
Higher doses: ulcers, dizziness, hair loss

24
Q

What is a mutation due to radiation?

A

Chromosomes containing the genetic blueprint are passed down for generations UNLESS genetic mutation caused by external factor.

25
What is a genetic mutation?
A permanent change in DNA sequence. Mutations inherited from a parent if mutation was present in sperm/egg cells.
26
What are somatic mutations?
NOT passed down to next generations. Occurred at some point in life due to environments factors OR if mistake was made when DNA replicated itself during cell division.
27
What are radiation effects from an embryo?
Can occur just after fertilization if woman is exposed while pregnant. Effects: smaller head/brain size, poorly formed eyes, abnormally slow growth and intellectual disability.
28
What is the most sensitive period for radiation effects to an embryo?
9th day of the 6th week after conception (organs are developing)
29
What are cataracts?
Clouding of the lens = image is blurred.
30
What is the definition of cancer?
Uncontrolled growth of abnormal cells. Abnormal change in nucleus of a cell initiates uncontrolled, rapid cell multiplication forming malignant tumours.
31
When do tumours grow?
When normal cells suffer from DNA mutation, multiplying with unusual restrictions.
32
Cancer from radiation especially affects what organs?
Blood forming organs.
33
What is the recovery period?
Time required for damage to tissues be repaired by inherent repair mechanisms.
34
What is the latent period?
Time between initial exposure and when effects become evident.
35
What happens to people exposed to 5 Sv of acute radiation exposure?
Death to 50% of people within 30 days
36
What happens to people exposed to 8-10 Sv of acute radiation exposure?
Death to most
37
What happens to people exposed to 10+ Sv of acute radiation exposure?
Death is certain within an hour
38
Who is the ICRP and when were they formed?
International Commission on Radiological Protection - 1928
39
What does the ICRP do?
Provides recommendations based on the current understanding of science of radiation exposure and effects.
40
ICRP 2010 supports 3 main principles:
1. Justification - only use if leads to a positive benefit 2. Optimization of Protection - exposure kept to ALARA 3. Dose Limitation - max dose must not pose a risk to person greater than working in a safe environment
41
What is MPD?
Maximum permissible dose - follows recommendations from ICRP, CNSC establishes limits
42
MPD for non-NEW in 1 year?
1 mSv
43
MPD for NEW over a year?
50 mSv
44
For 2 Gy of gamma radiation, what is the weighing factor?
One
45
For 2 Gy of alpha radiation, what is the weighing factor?
20
46
What are the main sources of background/natural radiation?
Cosmic radiation (sun/outer space) and terrestrial radiation (radioactive elements in Earth’s crust)
47
What’s the difference between internal and external exposure?
Internal: ingesting radioactive material and external: exposed to radiation
48
MPD for a pregnant NEW after she notifies her boss in writing?
4 mSv
49
Max permissible yearly dose for a NEW on: skin, hands & feet, lens of eye
Skin: 500 mSv Hands & Feet: 500 mSv Lens of Eye: 150 mSv
50
What is LD50?
Approx 5 Sv — acute radiation exposure = death to 50% people exposed in 30 days
51
0-250 mSv of acute exposure?
No injury evident/biological defects
52
1-2 Sv of acute exposure?
Radiation sickness
53
What organs/tissues have highest sensitivity?
Blood forming organs (spleen, bone marrow, lymph nodes) AND sex organs, lens of eye, digestive/respiratory system
54
What tissues are radiation resistant?
Connective tissues (muscles, tendons, ligaments), fat and bone, nerves and brain
55
What 2 elements are naturally occurring in the Earth’s Crust?
Uranium and thorium