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5-HT and migrane Flashcards

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1
Q

buspirone

A

5-HT1 partial agonist

Non-benzodiazepine anxiolytic

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2
Q

dexfenfluramine

A

5-HT2c agonist

Appetite suppression

Withdrawn due to toxicity

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3
Q

cisapride

A

5-HT4 agonist

Used for treatment of GERD and motility dissorders

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4
Q

almotriptan

A

selective 5-HT1d and 5-HT1b receptor agonist

oral

  • 5-HT1b/1d agonists (sumatriptan)
    • Inhbition of release of the vasodilating peptide calcitonin gene related peptide (CGRP)
    • Constrict cerebral and meningeal vessels in treatment of actue migrane headaches
    • Efficacy agasint migrane similar to other classes of drugs
    • Adverse effects including: tingling or warmth, sensations, dizziness, muscle weakness, neck pain, chest discomfort (vasospasm, angina - it can feel like this)
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5
Q

eletriptan

A

selective 5-HT1d and 5-HT1b receptor agonist

oral

  • 5-HT1b/1d agonists (sumatriptan)
    • Inhbition of release of the vasodilating peptide calcitonin gene related peptide (CGRP)
    • Constrict cerebral and meningeal vessels in treatment of actue migrane headaches
    • Efficacy agasint migrane similar to other classes of drugs
    • Adverse effects including: tingling or warmth, sensations, dizziness, muscle weakness, neck pain, chest discomfort (vasospasm, angina - it can feel like this)
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6
Q

frovatriptan

A

selective 5-HT1d and 5-HT1b receptor agonist

oral

  • 5-HT1b/1d agonists (sumatriptan)
    • Inhbition of release of the vasodilating peptide calcitonin gene related peptide (CGRP)
    • Constrict cerebral and meningeal vessels in treatment of actue migrane headaches
    • Efficacy agasint migrane similar to other classes of drugs
    • Adverse effects including: tingling or warmth, sensations, dizziness, muscle weakness, neck pain, chest discomfort (vasospasm, angina - it can feel like this)
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7
Q

naratriptan

A

selective 5-HT1d and 5-HT1b receptor agonist

oral

  • 5-HT1b/1d agonists (sumatriptan)
    • Inhbition of release of the vasodilating peptide calcitonin gene related peptide (CGRP)
    • Constrict cerebral and meningeal vessels in treatment of actue migrane headaches
    • Efficacy agasint migrane similar to other classes of drugs
    • Adverse effects including: tingling or warmth, sensations, dizziness, muscle weakness, neck pain, chest discomfort (vasospasm, angina - it can feel like this)
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8
Q

rizatriptan

A

selective 5-HT1d and 5-HT1b receptor agonist

oral

  • 5-HT1b/1d agonists (sumatriptan)
    • Inhbition of release of the vasodilating peptide calcitonin gene related peptide (CGRP)
    • Constrict cerebral and meningeal vessels in treatment of actue migrane headaches
    • Efficacy agasint migrane similar to other classes of drugs
    • Adverse effects including: tingling or warmth, sensations, dizziness, muscle weakness, neck pain, chest discomfort (vasospasm, angina - it can feel like this)
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9
Q

sumatriptan

A

selective 5-HT1d and 5-HT1b receptor agonist

oral

  • 5-HT1b/1d agonists (sumatriptan)
    • Inhbition of release of the vasodilating peptide calcitonin gene related peptide (CGRP)
    • Constrict cerebral and meningeal vessels in treatment of actue migrane headaches
    • Efficacy agasint migrane similar to other classes of drugs
    • Adverse effects including: tingling or warmth, sensations, dizziness, muscle weakness, neck pain, chest discomfort (vasospasm, angina - it can feel like this)
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10
Q

zolmitriptan

A

selective 5-HT1d and 5-HT1b receptor agonist

oral

  • 5-HT1b/1d agonists (sumatriptan)
    • Inhbition of release of the vasodilating peptide calcitonin gene related peptide (CGRP)
    • Constrict cerebral and meningeal vessels in treatment of actue migrane headaches
    • Efficacy agasint migrane similar to other classes of drugs
    • Adverse effects including: tingling or warmth, sensations, dizziness, muscle weakness, neck pain, chest discomfort (vasospasm, angina - it can feel like this)
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11
Q

phenoxybenzamine

A

5-HT2 antagoinst

  • Long acting 5-HT2 antagonists (+ alpha adrenergic receptors)
    *
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12
Q

cyproheptadine

A

5-HT2 antagonist

  • Cyprohepatidine
    • 5-HT2 antagonist and H1 receptor antagonist
    • Useful for the SM effects of carcinoid tumors
    • Serotonin syndorme treatment
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13
Q

alosetron

A

5-HT3 receptor antagonist

treatment of IBS drug

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14
Q

ondansetron, granisetron, dolasetron

A

5-HT3 receptor antagonist

  • Ondansetron, granisetron, dolasetron
    • 5-HT3 receptor antagonists
    • Treatment of nausea and vomiting in cancer chemo
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15
Q

dihydroergotamine

A

non selective 5-HT agonist

ergot derivative

taking with caffene may help absorption

Mechanism - vasoconstriction due to stimulation of alpha and 5-HT receptors

Disadvantages

Complex pharmacology/kinetics

Potent and sustained vasoconstrictor effects

Increased risk of vascular effects - contraindicated in patients with CAD

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16
Q

ergonovine

A

non selective 5-HT agonist

ergot derivative

taking with caffene may help absorption

Mechanism - vasoconstriction due to stimulation of alpha and 5-HT receptors

Disadvantages

Complex pharmacology/kinetics

Potent and sustained vasoconstrictor effects

Increased risk of vascular effects - contraindicated in patients with CAD

Ergonovine is the most selective for the uterus

If oxytocin fails, is utilized to limit post partum hemorrhage

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17
Q

ergotamine mixtures, ergotamine tartrate

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A

non selective 5-HT agonist

  • Taking with caffeine may help absorption
  • Mechanism - vasoconstriction due to stimulation of alpha and 5-HT receptors
  • Disadvantages
    • Complex pharmacology/kinetics
    • Potent and sustained vasoconstrictor effects
      • Increased risk of vascular effects - contraindicated in patients with CAD
18
Q

methylergonovine

Study These Flashcards
A

non selective 5-HT agonist

  • Taking with caffeine may help absorption
  • Mechanism - vasoconstriction due to stimulation of alpha and 5-HT receptors
  • Disadvantages
    • Complex pharmacology/kinetics
    • Potent and sustained vasoconstrictor effects
      • Increased risk of vascular effects - contraindicated in patients with CAD
19
Q

methysergide

Study These Flashcards
A

non selective 5-HT agonist

serotonin antaboinsts

AE: drowsiness, leg cramp, hair loss, retrorbital fibrosis

20
Q

lysergic acid diethylamine

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A

LSD - non selective 5-HT agonist

no clinical use

21
Q

ergotamine

Study These Flashcards
A

non selective 5-HT agonist

Ergotamine: potent vasoconstrictor

22
Q

ergocryptine

Study These Flashcards
A

non selective 5-HT agonist

23
Q

bronmocriptine

Study These Flashcards
A

non selective 5-HT agonist

24
Q

cabergoline

Study These Flashcards
A

non selective 5-HT agonist

25
propranolol
B blocker - used in preventive therapy for migranes
26
metoprolol
B blocker - used in preventive therapy for migranes
27
amitriptyline
antidepressant - used in preventive threapy for migrane drowsyness
28
divalproex
anticonvulsant - used in preventive threapy for migrane weight gain, tremor, hari loss, hemotological and liver problems, teratogenicity
29
topiramate
anticonvusant - used in preventive threapy for migrane weight gain, tremor, hari loss, hemotological and liver problems, teratogenicity
30
flunarizine
CCB - used in preventive threapy for migrane tiredness, weight gain, depression ,parkinsonism
31
verapamil
CCB - used in preventive threapy for migrane constipation, leg swelling, arterioventricular conduction disturbances
32
methysergide
serotonin antagonist - used in preventive threapy for migrane (withdrawn)
33
fluoxetine
prozac - SSRI - used in preventive threapy for migrane anxiety, insomnia
34
metoclopramide
antiemetic - used in migrane acute attacks ## Footnote Adjunctive therapy to combat nausea and vomiting due to migraine or ergot alkaloid treatment Centrally acting dopamine receptor antagonists
35
chlorpromazine
antiemetic - used in migrane acute attacks ## Footnote Adjunctive therapy to combat nausea and vomiting due to migraine or ergot alkaloid treatment Centrally acting dopamine receptor antagonists
36
prochlorperazine
antiemetic - used in migrane acute attacks ## Footnote Adjunctive therapy to combat nausea and vomiting due to migraine or ergot alkaloid treatment Centrally acting dopamine receptor antagonists
37
NSAIDs
- used in migrane acute attacks not selective for migranes - can have other probelms * Non specific pain therapy * Aspirin * Naproxen, ibuprofen (NSAIDs) * Acetaminophen * Geneally poorly effects - can also get sensitized to the pain
38
meperidine
opiates - used in migrane acute attacks not selective for migranes - can have other probelms * Meperidine, butophanol, oxycodone, hydromorphone * AE * Rebound headaches, dizziness, nausea, vomiting, impaired cognitive function, constipation
39
butorphanol
opiate - used in migrane acute attacks not selective for migranes - can have other probelms * Meperidine, butophanol, oxycodone, hydromorphone * AE * Rebound headaches, dizziness, nausea, vomiting, impaired cognitive function, constipation
40
oxycodone
opiates - used in migrane acute attacks not selective for migranes - can have other probelms * Meperidine, butophanol, oxycodone, hydromorphone * AE * Rebound headaches, dizziness, nausea, vomiting, impaired cognitive function, constipation
41
hydromorphone
opiate - used in migrane acute attacks not selective for migranes - can have other probelms * Meperidine, butophanol, oxycodone, hydromorphone * AE * Rebound headaches, dizziness, nausea, vomiting, impaired cognitive function, constipation

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