Flashcards in 5. Osteoarthritis and Reactive Arthritis Deck (28)
Recall the joints most commonly affected by osteoarthritis
In the hand: 1st CMC to thumb, PIPs, DIPs
Weight bearers (hips, knees)
What is the cause of osteoarthritis?
Excessive loading on joints
Describe the normal composition of synovial fluid
Rich in hyaluronic acid
Describe the normal composition of articular cartilage
Rich in type II collagen and aggrecan
What is the purpose of aggrecan and where is it found in joints?
Negative charge retains water
Found in articular cartilage
Recall 3 pathological changes seen in osteoarthritis
What is the consequence of chondrocyte apoptosis in osteoarthritis?
Subsequent bone damage, leading to node formation
Recall 2 clinical features of osteoarthritis
Heberden's nodes (at DIPs)
Bouchard's nodes (at PIPs)
How does activity affect joint pain in osteoarthritis?
Makes it worse since it is a mechanical aetiology
Recall 4 features of the joints in osteoarthritis
What is an osteophyte?
Radiological image of a joint swelling
Recall a unique radiological feature of osteoarthritis
Recall a radiographic feature that is common to both osteoarthritis and rheumatoid arthritis?
What is the gold standard treatment for osteoarthritis?
How is reactive arthritis defined?
Sterile inflammation of joint following infection
What sort of joints are affected by osteoarthritis?
Describe the pattern and sort of joints are affected by reactive arthritis?
Only large joints
What sorts of infection are most likely to result in reactive arthritis?
Urogenital or GIT
What particular viruses are associated with reactive arthritis?
Which gender is most likely to be affected by rheumatoid arthritis?
Females (it's AI)
Which gender is most likely to be affected by reactive arthritis?
What age group is most likely to be affected by reactive arthritis?
Recall 4 important extra-articular manifestations of reactive arthritis
Recall the HLA association of reactive arthritis
Recall 3 important diagnostic tests for reactive arthritis?
1. Microbiology sample of synovial fluid
2. RF (to exclude rheumatoid)
3. Synovial fluid exam (one joint affected indicates septic arthritis)
Recall 3 inflammatory manifestations of reactive arthritis outside of the joints
What is the name of the psoriasis-like rash seen in reactive arthritis