5. Osteoarthritis and Reactive Arthritis Flashcards Preview

LCRS Y2: Musculoskeletal > 5. Osteoarthritis and Reactive Arthritis > Flashcards

Flashcards in 5. Osteoarthritis and Reactive Arthritis Deck (28)
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1

Recall the joints most commonly affected by osteoarthritis

In the hand: 1st CMC to thumb, PIPs, DIPs
Spine
Weight bearers (hips, knees)

2

What is the cause of osteoarthritis?

Excessive loading on joints

3

Describe the normal composition of synovial fluid

Rich in hyaluronic acid

4

Describe the normal composition of articular cartilage

Rich in type II collagen and aggrecan

5

What is the purpose of aggrecan and where is it found in joints?

Negative charge retains water
Found in articular cartilage

6

Recall 3 pathological changes seen in osteoarthritis

Reduced aggrecan
Reduced collagen
Chondrocyte apoptosis

7

What is the consequence of chondrocyte apoptosis in osteoarthritis?

Subsequent bone damage, leading to node formation

8

Recall 2 clinical features of osteoarthritis

Heberden's nodes (at DIPs)
Bouchard's nodes (at PIPs)

9

How does activity affect joint pain in osteoarthritis?

Makes it worse since it is a mechanical aetiology

10

Recall 4 features of the joints in osteoarthritis

Pain
Crepitus
Instability
Enlargement (nodes)

11

What is an osteophyte?

Radiological image of a joint swelling

12

Recall a unique radiological feature of osteoarthritis

Osteophytes

13

Recall a radiographic feature that is common to both osteoarthritis and rheumatoid arthritis?

Joint narrowing

14

What is the gold standard treatment for osteoarthritis?

Joint replacement

15

How is reactive arthritis defined?

Sterile inflammation of joint following infection

16

What sort of joints are affected by osteoarthritis?

Synovial

17

Describe the pattern and sort of joints are affected by reactive arthritis?

Asymmetrical
Oligoarticular
Only large joints

18

What sorts of infection are most likely to result in reactive arthritis?

Urogenital or GIT

19

What particular viruses are associated with reactive arthritis?

Hep C
HIV

20

Which gender is most likely to be affected by rheumatoid arthritis?

Females (it's AI)

21

Which gender is most likely to be affected by reactive arthritis?

Men

22

What age group is most likely to be affected by reactive arthritis?

20-40

23

Recall 4 important extra-articular manifestations of reactive arthritis

Enthesopathy
Psoriasis-like rash
Spondylitis
Urethritis

24

Recall the HLA association of reactive arthritis

HLA-B27

25

Recall 3 important diagnostic tests for reactive arthritis?

1. Microbiology sample of synovial fluid
2. RF (to exclude rheumatoid)
3. Synovial fluid exam (one joint affected indicates septic arthritis)

26

Recall 3 inflammatory manifestations of reactive arthritis outside of the joints

Achilles tendonitis
Plantar fasciitis
Dactylitis

27

What is the name of the psoriasis-like rash seen in reactive arthritis

Keratoderma blenorrhagicum

28

Recall the management strategy for reactive arthritis

NSAIDS
Corticosteroids
NO antibiotics
May use topical steroid for extra-articular manifestations