Flashcards in 3. Pathogenesis of autoimmune disease Deck (53)
Upon which cells is HLA 1 and 2 presented?
HLA 1 = all cells
HLA 2 = APCs
What sort of antigens are presented by MHC 1 and 2
MHC1 = endogenous
MHC2 = exogenous
What class of T cells is involved in recognising MHC1 and 2?
MHC1 = CD8+
MHC2 = CD4+
Recall the general pathogenesis of AID
Ag binds HLA to trigger disease
Recall the HLA association of anklyosing spondylitis
Recall the HLA association of rheumatoid arthritis
Recall the HLA association of SLE
What class of HLA are HLA-B molecules?
What class of HLA are HLA-DR molecules?
What sort of auto-antibody is associated with rheumatoid arthritis?
What is ankylosing spondylitis?
Chronic spinal inflammation, leading to spinal fusion and deformity
What is enthesitis?
Inflammation where a tendon inserts into the bone
What antibodies are associated with ankyloing spondylitis?
None - it is seronegative
Recall 2 extra-articular associations of ankylosing spondylitis
IBD + enterpathic synovitis
What if the main form of inflammation in ankylosing spondylitis?
What is the main driver of inflammation in SLE?
Which autoantibodies are present in SLE?
Where does SLE cause inflammation?
Recall the site of production and effect(s) of gamma-IFN
Recall the site of production and effect(s) of IL1
Activates T cells
Recall the site of production and effect(s) of IL2
Activates T and B cells
Recall the site of production and effect(s) of IL6
Activates B cells
Recall the site of production and effect(s) of TNF alpha
Similar to IL1 but more destructive
Activates T cells
Which cytokine is particularly important for bone destruction in rheumatoid arthritis?
By what sort of cells is RANK-L produced?
What is the effect of RANK-L binding to RANK?
What is the most important inflammatory mediator in rheumatoid arthritis?
What is the effect of TNF-alpha on bone?
It activates macrophages, which damage bone and cartilage
Recall 2 treatments for rheumatoid arthritis?