3. Pathogenesis of autoimmune disease Flashcards Preview

LCRS Y2: Musculoskeletal > 3. Pathogenesis of autoimmune disease > Flashcards

Flashcards in 3. Pathogenesis of autoimmune disease Deck (53)
Loading flashcards...
1

Upon which cells is HLA 1 and 2 presented?

HLA 1 = all cells
HLA 2 = APCs

2

What sort of antigens are presented by MHC 1 and 2

MHC1 = endogenous
MHC2 = exogenous

3

What class of T cells is involved in recognising MHC1 and 2?

MHC1 = CD8+
MHC2 = CD4+

4

Recall the general pathogenesis of AID

Ag binds HLA to trigger disease

5

Recall the HLA association of anklyosing spondylitis

HLA-B27

6

Recall the HLA association of rheumatoid arthritis

HLA-DR4

7

Recall the HLA association of SLE

HLA-DR3

8

What class of HLA are HLA-B molecules?

Class 1

9

What class of HLA are HLA-DR molecules?

Class 2

10

What sort of auto-antibody is associated with rheumatoid arthritis?

Anti-CCP
RF

11

What is ankylosing spondylitis?

Chronic spinal inflammation, leading to spinal fusion and deformity

12

What is enthesitis?

Inflammation where a tendon inserts into the bone

13

What antibodies are associated with ankyloing spondylitis?

None - it is seronegative

14

Recall 2 extra-articular associations of ankylosing spondylitis

Psoriatic arthritis
IBD + enterpathic synovitis

15

What if the main form of inflammation in ankylosing spondylitis?

Enthesitis

16

What is the main driver of inflammation in SLE?

Immune complexes

17

Which autoantibodies are present in SLE?

ANA
anti-dsDNA

18

Where does SLE cause inflammation?

Connective tissue

19

Recall the site of production and effect(s) of gamma-IFN

T cells:
Activates macrophages

20

Recall the site of production and effect(s) of IL1

Macrophages:
Activates T cells
Pyretic
Pro-inflammatory

21

Recall the site of production and effect(s) of IL2

T cells:
Activates T and B cells

22

Recall the site of production and effect(s) of IL6

T cells:
Activates B cells

23

Recall the site of production and effect(s) of TNF alpha

Similar to IL1 but more destructive
Activates T cells
Pyretic
Pro-inflammatory

24

Which cytokine is particularly important for bone destruction in rheumatoid arthritis?

RANK-L

25

By what sort of cells is RANK-L produced?

T cells
Synovial fibroblasts

26

What is the effect of RANK-L binding to RANK?

Osteoclast activation

27

What is the most important inflammatory mediator in rheumatoid arthritis?

TNF-alpha

28

What is the effect of TNF-alpha on bone?

It activates macrophages, which damage bone and cartilage

29

Recall 2 treatments for rheumatoid arthritis?

Anti-TNF-alpha
PG blockade

30

How do glucocorticoids affect the prostaglandin production pathway?

Inhibit PLA2, the enzyme that liberates arachdionic acid from cell membranes