Botox

Question 1

Muscle weakness is seen at 2-4days whilst max paralysis at 7-10 days

Answer 1

T

Question 2

Peripheral nerves sprout new smaller unmyelinated nerve endings within 1 month after Botox

Answer 2

T

Question 3

Nerve repair is complete after 9 months - a functional connection is re established

Answer 3

F

3 months

Question 4

Muscular hypertrophy may be seen with each Botox injection

Answer 4

F

Atrophy

Question 5

Botox is extremely potent

Answer 5

T

Question 6

Botox 1U is amount required to kill 50% of mice when injected peritoneallly

Answer 6

T

Question 7

LD50 For Humans = 250-350 intraperitoneal Botox units

Answer 7

F

2500-3500

Question 8

Neutralizing antibodies are those that form against the surface of Botox

Answer 8

F

Forms against the core

Question 9

Botox a vials must be kept refrigerated

Answer 9

T

Question 10

Evaluation of eyelid laxity with a snap test is important prior to periocular tx

Answer 10

T

Question 11

Botox serotypes B, D, F and G catalyse cleavage of snare protein SNAP-25

Answer 11

F

Synaptobrevin AKA VAMP

ACE catalyse this protein