Bipolar disorder

Question 1

What is Disruptive Mood dysregulation?

Answer 1

Recurrent temper outbursts in response to common stressors

• begins at age 10
• at least 3 per week
• occurs in at least 2 settings

Question 2

What are some examples of emotional regulation?

Answer 2

• reactive attachement disorder
• infants of depresses mothers
• fetal alcohol spectrum disorder
• PTSD
• Personality disorders

Question 3

What are the genetic states behind bipolar 1 disorder?

Answer 3

50-80% twin-twin

- up to 85% heritability

Question 4

What are some neurophysiologic characteristics of bipolar disorder?

Answer 4

Limbic hyperactivity

• deactivation in the inferior frontal cortex or ventrolateral prefrontal cortex
• not in euthymic and depressed states

Question 5

what are the 2 hypothesis’ fro monoamine hypothesis?

Answer 5

• Monoamine hypothesis

- Neurotransmitter receptor hypothesis

Question 6

What is the suicide rate for bipolar disorder and MD?

Answer 6

> 10% and

Question 7

What is axis I and axis II?

Answer 7

Mood, attn, and substance abuse for I

- 2= personality disorders

Question 8

What are the only 2 drugs that have shown to demonstrate reduction in suicidal thoughts?

Answer 8

Lithium carbonate and clozapine?

Question 9

What are some of the side effects of depkote?

Answer 9

Hepatotoxicity and thrombocytopenia

Question 10

What should one monitor for a pt on Tegretol?

Answer 10

Agranulocytosis

hepatotoxicity

Question 11

What are some atypical antipsychotics? AKA neuroleptics

Answer 11

risperidone (Risperdal)
olanzapine (Zyprexa)
quetiapine (Seroquel)
ziprasidone (Geodon)
aripiprazole (Abilify)
asenapine (Saphris)
iloperidone (Fanapt)
Haloperidol (Haldol)
Fluphenazine (Prolixin)
Thioridazine (Mellaril)
Chlorpromazine (Thorazine)

Question 12

What is neuroleptic malignant syndrome?

Answer 12

Potentially fatal condition with loss of body temp regulation, renal and respiratory failure, ANS impairment and LOC

Question 13

What is the treatment for acute mania?

Answer 13

Lithium, Valproic acid and carbamazepine

• 2nd line neuroleptics
• ECT

Question 14

What is the treatment for acute/chronic depression?

Answer 14

• Stage 1 is lamotrigine (Lamictal) +/- mood stabilizer or neuroleptic
• Stage 2 is quetiapine (Seroquel) or olanzapine (Zyprexa) + fluoxetine (Prozac) combination
• Later stages involve other antidepressants + an antimanic agent