Important cytokines Flashcards
1
Q
IL-1
A
- AKA osteoclast activating factor
- Causes fever, acute inflammation
- Activates endothelium to express adhesion molecules
- Induces chemokine secretion to recruit WBCs
- Secreted by macrophages
2
Q
IL-6
A
- Causes fever and stimulates produce of acute phase proteins
- Secreted by macrophages
3
Q
IL-8
A
- Major chemotactic for neutrophils
- Secreted by macrophages
4
Q
IL-12
A
- Induces differentiation of T cells into Th1 cells
- Activates NK cells
- Secreted by macrophages
5
Q
TNF-alpha
A
- Mediates septic shock
- Activates endothelium
- Causes WBC recruitment, vascular leak
- Causes cachexia in malignancy
- Secreted by macrophages
6
Q
IL-2
A
- Stimulates growth of helper, cytotoxic and regulatory T cells
- Stimulates growth of NK cells
- Secreted by all T cells
7
Q
IL-3
A
- Supports growth and differentiation of bone marrow stem cells
- Functions like GM-CSF
- Secreted by all T cells
8
Q
Interferon-gamma
A
- Secreted by NK cells and T cells in response to IL-12 from macrophages
- Stimulates macrophages to kill phagocytosed pathogens
- Inhibits differentiation of Th2 cells
- Activates NK cells to kill virus infected cells
- Increases MHC expression and antigen presentation by all cells
- Secreted by Th1 cells
9
Q
IL-4
A
- Induces differentiation of T cells into Th2 cells
- Promotes growth of B cells
- Enhances class switching to IgE and IgG
- Secreted by Th2 cells
10
Q
IL-5
A
- Promotes growth and differentiation of B cells
- Enhances class switching to IgA
- Stimulates growth and differentiation of eosinophils
- Secreted by Th2 cells
11
Q
IL-10
A
- Attenuates inflammatory response
- Decreases expression of MHC class II and Th1 cytokines
- Inhibits activated macrophages and dendritic cells
- Also secreted by regulatory T cells
- TGF-beta and IL-10 both atTENuate the immune response
- Secreted by Th2 cells
12
Q
Secreted by macrophages
A
- IL-1
- IL-6
- IL-8
- IL-12
- TNF-alpha
13
Q
Secreted by all T cells
A
- IL-2
- IL-3
14
Q
Secreted by Th1 cells
A
- Interferon-gamma
- IL-2
- IL-3
15
Q
Secreted by Th2 cells
A
- IL-4
- IL-5
- IL-10
- IL-2
- IL-3
