Signaling pathways of endocrine hormones

Question 1

cAMP

Answer 1

• FSH
• LH
• ACTH
• TSH
• CRH
• hCG
• ADH (V2 receptors)
• MSH
• PTH
• Calcitonin
• GHRH
• Glucagon

“FLAT ChAMP”

Question 2

cGMP

Answer 2

• BMP
• ANP
• EDRF (NO)

“BAD GraMPa”
Think vasodilators.

Question 3

IP3

Answer 3

• GnRH
• Oxytocin
• ADH (V1 receptror)
• TRH
• Histamine (H1 receptor)
• Angiotensin II
• Gastrin

“GOAT HAG”

Question 4

Intracellular receptor

Answer 4

• Progesterone
• Estrogen
• Testosterone
• Cortisol
• Aldosterone
• T3/T4
• Vitamin D

“PET CAT on TV”

Question 5

Receptor tyrosine kinase

Answer 5

• Insulin
• IGF-1
• FGF
• PDGF
• EGF

MAP kinase pathway
Think growth factors

Question 6

Nonreceptor tyrosine kinase

Answer 6

• Prolactin
• Immunomodulators (eg cytokines IL-2, IL-6, IFN)
• GH
• G-CSF
• Erythropoietin
• Thrombopoietin

“PIGGLET”
JAK/STAT pathway
Think acidophils and cytokines