SCC/BCC

Question 1

What are the traits of Basal Cell CA?

Answer 1

Rarely Mets
Local aggresion and tissue destruction
SUN EXPOSURE
Pearly Papules cont prominent dilated SubEpi BV

Question 2

What is the Tx of BCC?

Answer 2

Excision/Destruction
Small: Cryo/Electrosurg
Topical 
Radiation
Moh's Surgery

Question 3

What is Moh’s Surgery?

Answer 3

Micro Control for lesions in anatomically sensitive areas

Question 4

What is the pathology of BCC?

Answer 4

Nodules attached to the Dermis. Cells line up along nodules. (Along Derm/Epiderm border)

Question 5

What are the traits of Gorlin Syndrome?

Answer 5

AD

Mutation of PTCH Gene on Chromosome 9 (tumor supressor- mutation allows SHH => Cell growth)

Question 6

What are the Causes of Squamous Cell CA?

Answer 6

Caused by UV exposure, HPV, Carcinogens, Chron, ulcers

IMMUNOSUPRESSION

Question 7

What are the Traits of SCC?

Answer 7

Associated with Actinic Keratosis
Firm Hyperkeratotic Plaque
Can have Erosions and Crusts
Locally Destructive
CAN Mets

Question 8

SCC in ___________ are most likely to mets.

Answer 8

Ear, Lip, Genitalia

Question 9

What is the Tx of SCC?

Answer 9

Excision- Mohs in diff site

Radiation if surgery not sucessful/Feasable

Question 10

What is the Path of SCC?

Answer 10

Proliferation of the Spinous layer of the epidermis

Question 11

What are the Prognostic facotrs of SCC?

Answer 11

Size >4cm
Depth of invasion
Neurotropism
Acantholytic PAttern

Question 12

What are the Traits of Verrucous CA?

Answer 12

Low Grade/ Well Diff variant
Sole of Foot most common
(Sinus Tract?)

Question 13

What are the traits of Anogenital Verrucous CA?

Answer 13

Condyloma Accuminata
HPV related (6 and 11)
Difficult to comtrol

Question 14

What are the traits of Keratoacanthoma?

Answer 14

Rapildy Devt Neoplasm
Mimics SCC
Flesh colored, dome shaped nodules with central keratin filled plug. Crater like

Question 15

What is the Tx of Keratocanthoma?

Answer 15

Surgical Excision

Question 16

What are trhe Traits of Actinic Keratosis?

Answer 16

Squamous Dysplasia (Buildup of Excess keratin)

Question 17

What is the management of AK?

Answer 17

Prev w/ sunscreen!
Cryosurgery
5-FU
Topical Retinoids
Facial Peels
Follow-up w/ monitoring for SCC

Question 18

What are the Traits of Bowenoid Papulosis?

Answer 18

Variant of SCCIS
Anogenital, HPV related
Young SA Adults
Small reddish brown papules
Histo ID to Bowen's

Question 19

WHat are the Traits of Xeroderma Pigmentosum?

Answer 19

AR

Sun sensitivity- Sunburn w/ min exposure

Question 20

What is the PAthophys of Xeroderma Pigmentosum?

Answer 20

Mult genetic Defects

Can’t repair DNA damage from UV radiation

Question 21

What are the Traits of Merkel Cell CA?

Answer 21

Resembles Mets SCC

Question 22

What are the cancers that Most commonly mets to the skin?

Answer 22

Lung
Colon
Melanoma
Oral SCC
Females: BREAST (69%)

Question 23

What is a sister MAry Joseph Nodule?

Answer 23

Cancer in the Umbilicus a sign of cancer of the abdomen

Question 24

What are the Traits of Mammary Paget’s Disease?

Answer 24

Associated with Mammary Ductal CA

Mistaken for Eczema or psoriasis

Question 25

What are the traits of Atypical Fibroxanthoma?

Answer 25

Sun exposed and actinically damaged areas. Head and Neck of elderly
Firm solitary nodule +/- Ulceration

Question 26

What is the Pathology of AFX?

Answer 26

Pleomorphic Spindle Cell tumor w/ increased mitotic activity

Dx of Exclusion

Question 27

What are the Types of Kaposi Sarcoma?

Answer 27

• Classic Endemic - Distal ext: Med/Jew pop
• AIDS Related: HHV8
• Immunosupression rel
• African- Sub Saharan