Antibiotic Resistance

Question 1

Vancomycin

Answer 1

inserts lactic acid in place of terminal D-ALA

common in ternococcus

Question 2

Amino glycoside

• (kill or inhibit growth?)
• mech

Answer 2

bactericidal

from plasma encoded enzymes that modify amino sugars that are added to OH or amino groups-so can’t bind to 30S ribosome

some resistances have been beaten by moleoal of OH groups or addition of kargebulky groups

Question 3

Macrolide and Streptogrammins

Answer 3

bactericidal

adds emthl group to base of RNA in 50S submit
-transposon ermA gene

Question 4

Tetracycline

Answer 4

bacteriostatic

tetracycline-encoded transport protein pumps out of cell