MDS/MPD

Question 1

CML Genetic Translocation

Answer 1

Abelson tyrosine kinase / BCR translocation

Question 2

AML-M3 genetic translocation

Answer 2

PML/RAR fusion protein. Retinoic acid causes differentiation of neutrophil

Question 3

ALL genetic translocation

Answer 3

BCR/ABL translocation

Question 4

Burkitt Lymphoma Translocation

Answer 4

Myc is transloated and under control of IGH. MYC is a powerful proto oncogene, bHLH transcription factor which recruits HATs

Question 5

Tcell Lymphoma translocation

Answer 5

MYC protooncogene is under Tcell Receptor Promoter

Question 6

PV genetic mutation

Answer 6

JAK is mutated, increasing kinase activity. Downstream of many cytokine receptors

Question 7

Li fraumeini disease

Answer 7

due to p53 tumor supressor mutation, prone to leukemia

Question 8

Fanconi Anemia

Answer 8

Defective DNA repair, leads to AML.

Question 9

ALL

Answer 9

Common in children, TdT and PAS positive, small to medium lymphoblasts, neutropenia, thrombocytopenia, anemia, lymphblasts and pro lymphocytes

Question 10

aml

Answer 10

common in adults, Sudan Black and MPO positive, medium to large myeloblasts, anemia, neutropenia, thrombocytopenia