52 MSK Manifestations of Systemic Disease Flashcards
T/F Rickets only affects children
T
Causes of rickets can be classified as either ___ or ___
1) Calcipenic
2) Osteopenic
Calcipenic rickets is mostly due to
1) Deficiency of the active form of Vitamin D (1,25-dihydroxyvitamin D3)
2) Calcium deficiency
Celiac disease, IBD, scleroderma, and liver disease can cause rickets due to
Impaired calcium absorption
Phosphopenic rickets is mostly due to
Renal wasting ofphosphate
Underlying biochemical abnormality in Vitamin D resistance resulting in rickets
Impaired parathormone-dependent proximal renal tubular reabsorption of phosphate
Underlying biochemical abnormality in Type 1 Vitamin D dependence
Defect in renal 1-α-hydroxylase
Underlying biochemical abnormality in Type 2 Vitamin D dependence
End-organ unresponsiveness to 1,25-dihydroxyvitamin D3
Underlying biochemical abnormality in hypophosphatasia
Decreased serum ALP
MC causes of rickets worldwide
1) Exclusion from the sun for social/cultural reasons
2) Insufficient dietary intake of vitamin D
T/F Rickets is uncommon in dark-skinned children living in colder climates
F, more common
Cause of rickets in developed countries despite adequate vitamin D intake
Impaired absorption because of GI problems
T/F Vitamin D insufficiency in infants can be compounded by breastfeeding
T
Group of medications that may interfere with Vitamin D metabolism
Anticonvulsant medications
Normal source of vitamin D3 in humans
Skin
