chapter 2: cell structures, virulence factors and toxins Flashcards

1
Q

the flagellum is affixed to the bacteria by the ___ ____ which spins around to move the flagellum

A

basal body

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2
Q

vibrio cholera has how many flagella

A

single

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3
Q

e coli flagella

also proteus mirabilis

A

many around the cell

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4
Q

shigella has ___ flagella

A

no

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5
Q

____ can serve as adherence factors called ___

and these are necessary for certain bacteria to cause virulence

A

pili

adhesins

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6
Q

which bacteria is unique in that its capsule is made up of amino acid residues

A

bacillus anthracis

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7
Q

what are capsules

A

protective walls that surround the cell membrane of bacteria

-usually made of simple sugar residues

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8
Q

how do capsules make bacteria more virulent

A

macrophages and neutorphils cannot phagocytize encapsulated bugs

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9
Q

what 2 tests enable doctors to visualize capsules under the microscope and aid in IDing bacteria

first one IDs what bacteria

A

india ink stain: appears as tranparent halo around cell
-identify cryptococcus
(halo around the crypt)

quellung reaction: bacteria mixed with Abs that bind capsule, when bind, capsule swells with water and this is visualized

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10
Q

how does our body get rid of encapsulated bacteria

A

Abs bind it, opsoninzing it which helps macrophages and neutrophils

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11
Q

endospores have a multilayered protective coat consisting of

A
cell membarne 
thick peptigoglycan mesh
another cell membrane 
wall of keratin like protein
outer layer called exosporium
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12
Q

biofilms fnct

A

allows bacteria to bind to prostetic devices like IV catheters
protects them from attack by antibiotics and immune system

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13
Q

whch bacteria forms biofilms on intravascular catheters and can cause catheter related sepsis

A

staphlyococcus epidermidis

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14
Q

facultative intracellular organisms

A

bacteria that get phagocytosed by macrophages and neutrophils but survive unharmed
-prevent phagosome-lysosome fusion

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15
Q

facultative intracellular organisms

A

listen sally yer friend bruce must leave now

listeria, salmonella, yersinia francisella brucella legionella mycobacterium nocardia

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16
Q

exotoxins are mainly secreted by what but certain gram ___ bacteria like ___ and ___ secrete them too

A

gram positive

gram negative like virbio cholera and E. Coli

17
Q

neurotoxins and examples

A

exotoxins that act on nerves or motor endplates that cause paralysis

tetanus toxin
botulinium toxin

18
Q

enterotoxin

A

exotoxins that act on GI tract to cause diarrhea

-inhibit NaCl absorption and cause its secretion

19
Q

enterotoxins cause 2 disease manifestations

examples

A

infectious diarrhea:
- V cholera, E coli, campylocbater jejuni, shigella dysenteriae

food poisoning:
bacillus cereus
staphylococcus aureus

20
Q

pyrogenic exotoxins stimulate release of ___ and can cause

examples

A

cytokines
can casue rash, fever, toxic shock

staphylococcus aureus
streptococcus pyogenes

21
Q

exotoxin subunits

A

2 polypeptide subunits bound together by disulfide bridges

B or H binds to target cell

A or L exerts toxic effect

22
Q

what is bacteremia

A

bacteria in the blood stream

23
Q

4 bacteria that produce exotoxins that increase levels of cAMP

A

cholera
anthrax
montezumas revenege (E coli)
pertussis

cAMP